Effect of flunixin meglumine on endogenous prostaglandin F secretion during cloprostenol-induced abortion in mares

P. F. Daels From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (Daels, Mohammed), and the Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, S-75007 Uppsala, Sweden (Odensvik, Kindahl).

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H. O. Mohammed From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (Daels, Mohammed), and the Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, S-75007 Uppsala, Sweden (Odensvik, Kindahl).

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Kristina Odensvik From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (Daels, Mohammed), and the Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, S-75007 Uppsala, Sweden (Odensvik, Kindahl).

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H. Kindahl From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (Daels, Mohammed), and the Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, S-75007 Uppsala, Sweden (Odensvik, Kindahl).

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Abstract

Objective

To determine the relative role of endogenous prostaglandin F (pgf secretion in cloprostenol-induced abortion in mares that no longer require luteal progesterone secretion for maintenance of pregnancy, and to evaluate the ability of a prostaglandin cyclooxygenase inhibitor (flunixin meglumine) to prevent cloprostenol-induced abortion.

Design

The effect of flunixin meglumine on pgf secretion and outcome of pregnancy was compared between mares treated with cloprostenol only and mares treated with cloprostenol plus flunixin meglumine.

Animals

Five pregnant mares, aged 4 to 15 years, of light-horse type.

Procedure

Cloprostenol (250 μg) was administered at 24-hour intervals to 5 pregnant mares. Flunixin meglumine (500 mg, iv) was administered at 8-hour intervals starting 15 minutes before the first cloprostenol administration. Hourly blood samples were analyzed for 15-ke-todihydro-pgf, progesterone, and estrogen concentrations. Previously reported data on cloprostenol-induced abortion in 6 pregnant mares treated daily with cloprostenol only were used as historic controls.

Results

The mean (± sem) interval from first cloprostenol administration to fetal expulsion 56.4 (± 13.7) hours and number of cloprostenol administrations 3.2 (± 0.6) in the 5 flunixin meglumine-treated mares were not significantly different, compared with values for 6 pregnant mares treated daily with cloprostenol only, 48.6 (± 5.6) hours and 2.8 (± 0.2) cloprostenol administrations. Flunixin meglumine did not inhibit endogenous pgf secretion. Prostaglandin F secretion rates on the day before and day of fetal expulsion were similar in both groups.

Conclusion

Flunixin meglumine at a dosage of 500 mg/animal, administered iv every 8 hours, is ineffective in modulating uterine pgf secretion during cloprostenol-induced abortion.

Clinical Relevance

Flunixin meglumine is ineffective in the modulation of prostaglandin-induced uterine pgfsecretion and, therefore, does not offer a viable alternative for the prevention of abortion in mares at risk of abortion because of systemic illness.

Abstract

Objective

To determine the relative role of endogenous prostaglandin F (pgf secretion in cloprostenol-induced abortion in mares that no longer require luteal progesterone secretion for maintenance of pregnancy, and to evaluate the ability of a prostaglandin cyclooxygenase inhibitor (flunixin meglumine) to prevent cloprostenol-induced abortion.

Design

The effect of flunixin meglumine on pgf secretion and outcome of pregnancy was compared between mares treated with cloprostenol only and mares treated with cloprostenol plus flunixin meglumine.

Animals

Five pregnant mares, aged 4 to 15 years, of light-horse type.

Procedure

Cloprostenol (250 μg) was administered at 24-hour intervals to 5 pregnant mares. Flunixin meglumine (500 mg, iv) was administered at 8-hour intervals starting 15 minutes before the first cloprostenol administration. Hourly blood samples were analyzed for 15-ke-todihydro-pgf, progesterone, and estrogen concentrations. Previously reported data on cloprostenol-induced abortion in 6 pregnant mares treated daily with cloprostenol only were used as historic controls.

Results

The mean (± sem) interval from first cloprostenol administration to fetal expulsion 56.4 (± 13.7) hours and number of cloprostenol administrations 3.2 (± 0.6) in the 5 flunixin meglumine-treated mares were not significantly different, compared with values for 6 pregnant mares treated daily with cloprostenol only, 48.6 (± 5.6) hours and 2.8 (± 0.2) cloprostenol administrations. Flunixin meglumine did not inhibit endogenous pgf secretion. Prostaglandin F secretion rates on the day before and day of fetal expulsion were similar in both groups.

Conclusion

Flunixin meglumine at a dosage of 500 mg/animal, administered iv every 8 hours, is ineffective in modulating uterine pgf secretion during cloprostenol-induced abortion.

Clinical Relevance

Flunixin meglumine is ineffective in the modulation of prostaglandin-induced uterine pgfsecretion and, therefore, does not offer a viable alternative for the prevention of abortion in mares at risk of abortion because of systemic illness.

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