Influence of four diets containing approximately 11% protein (dry weight) on uric acid, sodium urate, and ammonium urate urine activity product ratios of healthy Beagles

Joseph W. Bartges From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Koehler, Bird, Unger), and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, Paul, MN 55108; Mark Morris Institute (Allen), 5500 SW 7th St, Topeka, KS 66606; and the Department of Biochemistry and Molecular Biology (Brown) College of Medicine, University of Florida, PO Box 100275, Gainesville, FL 32610.

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Carl A. Osborne From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Koehler, Bird, Unger), and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, Paul, MN 55108; Mark Morris Institute (Allen), 5500 SW 7th St, Topeka, KS 66606; and the Department of Biochemistry and Molecular Biology (Brown) College of Medicine, University of Florida, PO Box 100275, Gainesville, FL 32610.

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Lawrence J. Felice From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Koehler, Bird, Unger), and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, Paul, MN 55108; Mark Morris Institute (Allen), 5500 SW 7th St, Topeka, KS 66606; and the Department of Biochemistry and Molecular Biology (Brown) College of Medicine, University of Florida, PO Box 100275, Gainesville, FL 32610.

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Timothy A. Allen From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Koehler, Bird, Unger), and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, Paul, MN 55108; Mark Morris Institute (Allen), 5500 SW 7th St, Topeka, KS 66606; and the Department of Biochemistry and Molecular Biology (Brown) College of Medicine, University of Florida, PO Box 100275, Gainesville, FL 32610.

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Charles Brown From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Koehler, Bird, Unger), and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, Paul, MN 55108; Mark Morris Institute (Allen), 5500 SW 7th St, Topeka, KS 66606; and the Department of Biochemistry and Molecular Biology (Brown) College of Medicine, University of Florida, PO Box 100275, Gainesville, FL 32610.

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Lori A. Koehler From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Koehler, Bird, Unger), and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, Paul, MN 55108; Mark Morris Institute (Allen), 5500 SW 7th St, Topeka, KS 66606; and the Department of Biochemistry and Molecular Biology (Brown) College of Medicine, University of Florida, PO Box 100275, Gainesville, FL 32610.

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Kathy A. Bird From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Koehler, Bird, Unger), and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, Paul, MN 55108; Mark Morris Institute (Allen), 5500 SW 7th St, Topeka, KS 66606; and the Department of Biochemistry and Molecular Biology (Brown) College of Medicine, University of Florida, PO Box 100275, Gainesville, FL 32610.

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Lisa K. Unger From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Koehler, Bird, Unger), and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, Paul, MN 55108; Mark Morris Institute (Allen), 5500 SW 7th St, Topeka, KS 66606; and the Department of Biochemistry and Molecular Biology (Brown) College of Medicine, University of Florida, PO Box 100275, Gainesville, FL 32610.

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Menglan Chen From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Koehler, Bird, Unger), and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, Paul, MN 55108; Mark Morris Institute (Allen), 5500 SW 7th St, Topeka, KS 66606; and the Department of Biochemistry and Molecular Biology (Brown) College of Medicine, University of Florida, PO Box 100275, Gainesville, FL 32610.

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SUMMARY

Urine activity product ratios of uric acid (aprua), sodium urate (aprna), and ammonium urate (aprau), and urinary excretion of 10 metabolites were determined in 24-hour urine samples produced by 6 healthy Beagles during periods of consumption of 4 diets containing approximately 11% protein (dry weight) and various protein sources: a 72% moisture, casein-based diet; a 10% moisture, egg-based diet; a 72% moisture, chicken-based diet; and a 71% moisture, chicken-based, liver-flavored diet. Significantly (P < 0.05) higher aprua, aprna, and aprau were observed when dogs consumed the egg-based diet, compared with the other 3 diets; there were no differences in these ratios among the other 3 diets.

Twenty-four-hour urinary excretions of chloride, potassium, phosphorus, and oxalic acid were significantly (P < 0.05) higher when dogs consumed the egg-based diet. Twenty-four-hour urinary excretions of sodium were significantly (P < 0.05) higher when dogs consumed the egg-based diet, compared with the casein-based diet and the chicken-based, liver-flavored diet, but were not significantly different between the egg-based diet and chicken-based diet. Twenty-four-hour urine volume was similar when dogs consumed the 4 diets. Twenty-four-hour endogenous creatinine clearance was significantly (P < 0.05 lower when dogs consumed the casein based diet there were no differences among the other 3 diets. Although consumption all diets was associated with production alkaline urine, the 24-hour urine pH was significantly (P < 0.05) higher when dogs consumed the egg-based diet.

These results suggest that use diets containing approximately 10.5% protein (dry weight) and 70 moisture protocols designed for dissolution and prevention urate uroliths may be beneficial. The source dietary protein in canned formulated diets does not appear significantly influence the saturation of urine with uric acid, sodium urate, or ammonium urate.

SUMMARY

Urine activity product ratios of uric acid (aprua), sodium urate (aprna), and ammonium urate (aprau), and urinary excretion of 10 metabolites were determined in 24-hour urine samples produced by 6 healthy Beagles during periods of consumption of 4 diets containing approximately 11% protein (dry weight) and various protein sources: a 72% moisture, casein-based diet; a 10% moisture, egg-based diet; a 72% moisture, chicken-based diet; and a 71% moisture, chicken-based, liver-flavored diet. Significantly (P < 0.05) higher aprua, aprna, and aprau were observed when dogs consumed the egg-based diet, compared with the other 3 diets; there were no differences in these ratios among the other 3 diets.

Twenty-four-hour urinary excretions of chloride, potassium, phosphorus, and oxalic acid were significantly (P < 0.05) higher when dogs consumed the egg-based diet. Twenty-four-hour urinary excretions of sodium were significantly (P < 0.05) higher when dogs consumed the egg-based diet, compared with the casein-based diet and the chicken-based, liver-flavored diet, but were not significantly different between the egg-based diet and chicken-based diet. Twenty-four-hour urine volume was similar when dogs consumed the 4 diets. Twenty-four-hour endogenous creatinine clearance was significantly (P < 0.05 lower when dogs consumed the casein based diet there were no differences among the other 3 diets. Although consumption all diets was associated with production alkaline urine, the 24-hour urine pH was significantly (P < 0.05) higher when dogs consumed the egg-based diet.

These results suggest that use diets containing approximately 10.5% protein (dry weight) and 70 moisture protocols designed for dissolution and prevention urate uroliths may be beneficial. The source dietary protein in canned formulated diets does not appear significantly influence the saturation of urine with uric acid, sodium urate, or ammonium urate.

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