Plasma concentration of atrial natriuretic peptide in relation to severity of mitral regurgitation in Cavalier King Charles Spaniels

Jens Häggström From the Departments of Physiology (Häggström, Kvart) and Clinical Radiology (Hansson), Faculty of Veterinary Medicine and the Department of Animal Physiology (Olsson), Faculty of Agriculture, University of Agricultural Sciences, 750 07 Uppsala, Sweden, and Clinical Research Center (Karlberg), Department of Internal Medicine, University Hospital, 581 85 Linköping, Sweden.

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Kerstin Hansson From the Departments of Physiology (Häggström, Kvart) and Clinical Radiology (Hansson), Faculty of Veterinary Medicine and the Department of Animal Physiology (Olsson), Faculty of Agriculture, University of Agricultural Sciences, 750 07 Uppsala, Sweden, and Clinical Research Center (Karlberg), Department of Internal Medicine, University Hospital, 581 85 Linköping, Sweden.

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Bengt E. Karlberg From the Departments of Physiology (Häggström, Kvart) and Clinical Radiology (Hansson), Faculty of Veterinary Medicine and the Department of Animal Physiology (Olsson), Faculty of Agriculture, University of Agricultural Sciences, 750 07 Uppsala, Sweden, and Clinical Research Center (Karlberg), Department of Internal Medicine, University Hospital, 581 85 Linköping, Sweden.

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Clarence Kvart From the Departments of Physiology (Häggström, Kvart) and Clinical Radiology (Hansson), Faculty of Veterinary Medicine and the Department of Animal Physiology (Olsson), Faculty of Agriculture, University of Agricultural Sciences, 750 07 Uppsala, Sweden, and Clinical Research Center (Karlberg), Department of Internal Medicine, University Hospital, 581 85 Linköping, Sweden.

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Kerstin Olsson From the Departments of Physiology (Häggström, Kvart) and Clinical Radiology (Hansson), Faculty of Veterinary Medicine and the Department of Animal Physiology (Olsson), Faculty of Agriculture, University of Agricultural Sciences, 750 07 Uppsala, Sweden, and Clinical Research Center (Karlberg), Department of Internal Medicine, University Hospital, 581 85 Linköping, Sweden.

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Summary

Plasma concentration of immunoreactive atrial natriuretic peptide (ir-anp) was investigated in 83 Cavalier King Charles Spaniels with variable severity of mitral regurgitation caused by chronic valvular disease (cvd). Severity of mitral incompetence was assessed by echocardiography. Significant differences in plasma concentrations of ir-anp were not found between clinically normal dogs (New York Heart Association functional class O), dogs with only cardiac murmur (class I), and dogs with echocardiographic evidence of slight to moderate left atrial and ventricular dilatation (class II). Dogs with severe left atrial and ventricular dilatation and clinical signs of congestion (classes III and IV) were found to have significantly (P < 0.001) increased plasma concentration of ir-anp. Overall, moderate degree of association was found between plasma concentration of ir-anp and left atrial and left ventricular diameters (Pearson's r = 0.65, 0.60, respectively, P < 0.001), as well as heart rate (r = 0.47, P < 0.01). However, left atrial enlargement was found to have the predominant effect on plasma ir-anp concentration. It is concluded that the plasma concentration of ir-anp did not become markedly increased before decompensation of chronic mitral regurgitation associated with severe enlargement of the left atrium and ventricle in Cavalier King Charles Spaniels.

Summary

Plasma concentration of immunoreactive atrial natriuretic peptide (ir-anp) was investigated in 83 Cavalier King Charles Spaniels with variable severity of mitral regurgitation caused by chronic valvular disease (cvd). Severity of mitral incompetence was assessed by echocardiography. Significant differences in plasma concentrations of ir-anp were not found between clinically normal dogs (New York Heart Association functional class O), dogs with only cardiac murmur (class I), and dogs with echocardiographic evidence of slight to moderate left atrial and ventricular dilatation (class II). Dogs with severe left atrial and ventricular dilatation and clinical signs of congestion (classes III and IV) were found to have significantly (P < 0.001) increased plasma concentration of ir-anp. Overall, moderate degree of association was found between plasma concentration of ir-anp and left atrial and left ventricular diameters (Pearson's r = 0.65, 0.60, respectively, P < 0.001), as well as heart rate (r = 0.47, P < 0.01). However, left atrial enlargement was found to have the predominant effect on plasma ir-anp concentration. It is concluded that the plasma concentration of ir-anp did not become markedly increased before decompensation of chronic mitral regurgitation associated with severe enlargement of the left atrium and ventricle in Cavalier King Charles Spaniels.

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