Reliability of single urine and serum samples for estimation of 24-hour urinary uric acid excretion in six healthy Beagles

Joseph W. Bartges From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Bird, Koehler) and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108.

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Carl A. Osborne From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Bird, Koehler) and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108.

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Lawrence J. Felice From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Bird, Koehler) and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108.

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Lisa K. Unger From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Bird, Koehler) and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108.

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Katherine A. Bird From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Bird, Koehler) and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108.

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Lori A. Koehler From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Bird, Koehler) and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108.

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Menglan Chen From the Departments of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Bird, Koehler) and Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108.

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Summary

Urine uric acid-to-urine creatinine ratios (uua:uc), urine uric acid concentrations, urine uric acid concentrations corrected for glomerular filtration rate, and urinary uric acid fractional excretions were compared with 24-hour urinary uric acid excretions measured in 6 healthy adult female Beagles. Comparisons, using correlation analysis, were made when dogs consumed a 10.4% protein (dry weight), casein-based diet and a 31.4% protein (dry weight), meat-based diet. The uua:uc, urine uric acid concentrations corrected for glomerular filtration rate, and urinary uric acid fractional excretions were not reliable estimates of 24-hour urinary uric acid excretions during consumption of either diet. Urine uric acid concentrations in samples collected 2, 4, 6, and 24 hours after initiation of collection correlated with 24-hour urinary uric acid excretions when dogs consumed the casein-based diet; correlation was not found at any time interval when dogs consumed the meatbased diet. Therefore, determination of 24-hour urinary uric acid excretion is recommended because uua:uc are unreliable.

Summary

Urine uric acid-to-urine creatinine ratios (uua:uc), urine uric acid concentrations, urine uric acid concentrations corrected for glomerular filtration rate, and urinary uric acid fractional excretions were compared with 24-hour urinary uric acid excretions measured in 6 healthy adult female Beagles. Comparisons, using correlation analysis, were made when dogs consumed a 10.4% protein (dry weight), casein-based diet and a 31.4% protein (dry weight), meat-based diet. The uua:uc, urine uric acid concentrations corrected for glomerular filtration rate, and urinary uric acid fractional excretions were not reliable estimates of 24-hour urinary uric acid excretions during consumption of either diet. Urine uric acid concentrations in samples collected 2, 4, 6, and 24 hours after initiation of collection correlated with 24-hour urinary uric acid excretions when dogs consumed the casein-based diet; correlation was not found at any time interval when dogs consumed the meatbased diet. Therefore, determination of 24-hour urinary uric acid excretion is recommended because uua:uc are unreliable.

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