Early insulin response to an intravenous glucose tolerance test in horses

A. Giraudet From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon Tharp St, Columbus, OH 43210-1089.

Search for other papers by A. Giraudet in
Current site
Google Scholar
PubMed
Close
 DMV
,
K. W. Hinchcliff From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon Tharp St, Columbus, OH 43210-1089.

Search for other papers by K. W. Hinchcliff in
Current site
Google Scholar
PubMed
Close
 BVSc, PhD
,
C. W. Kohn From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon Tharp St, Columbus, OH 43210-1089.

Search for other papers by C. W. Kohn in
Current site
Google Scholar
PubMed
Close
 VMD
, and
K. H. McKeever From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon Tharp St, Columbus, OH 43210-1089.

Search for other papers by K. H. McKeever in
Current site
Google Scholar
PubMed
Close
 PhD

Click on author name to view affiliation information

Summary

Plasma insulin concentration of many species has a characteristic early or acute-phase response in the minutes after IV administration of glucose. However, the plasma insulin response of horses soon after the IV administration of glucose has not been examined, whereas the more prolonged response has been evaluated. We examined the plasma insulin and glucose concentration responses of adult mares during the 30 minutes after rapid IV administration of glucose (0.33 g/kg of body weight). Plasma glucose concentration peaked at 664 ± 54 mg/dl within 1 minute of cessation of glucose administration, whereas insulin concentration peaked at 326 ± 24 pmol/L at 2 minutes after the end of glucose administration. Thus, these mares had an acute insulin response, consistent with that observed in other species, including dogs, human beings, and cattle.

Summary

Plasma insulin concentration of many species has a characteristic early or acute-phase response in the minutes after IV administration of glucose. However, the plasma insulin response of horses soon after the IV administration of glucose has not been examined, whereas the more prolonged response has been evaluated. We examined the plasma insulin and glucose concentration responses of adult mares during the 30 minutes after rapid IV administration of glucose (0.33 g/kg of body weight). Plasma glucose concentration peaked at 664 ± 54 mg/dl within 1 minute of cessation of glucose administration, whereas insulin concentration peaked at 326 ± 24 pmol/L at 2 minutes after the end of glucose administration. Thus, these mares had an acute insulin response, consistent with that observed in other species, including dogs, human beings, and cattle.

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 23 23 5
PDF Downloads 14 14 2
Advertisement