Effect of furosemide on plasma atrial natriuretic peptide and aldosterone concentrations and renin activity in running horses

J. L. Cooley From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine (Hinchcliff, McKeever, Muir), and Department of Exercise Physiology, School of Health, Physical Education, and Recreation (Cooley, Lamb), The Ohio State University, Columbus, OH 43210.

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K. W. Hinchcliff From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine (Hinchcliff, McKeever, Muir), and Department of Exercise Physiology, School of Health, Physical Education, and Recreation (Cooley, Lamb), The Ohio State University, Columbus, OH 43210.

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K. H. McKeever From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine (Hinchcliff, McKeever, Muir), and Department of Exercise Physiology, School of Health, Physical Education, and Recreation (Cooley, Lamb), The Ohio State University, Columbus, OH 43210.

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D. R. Lamb From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine (Hinchcliff, McKeever, Muir), and Department of Exercise Physiology, School of Health, Physical Education, and Recreation (Cooley, Lamb), The Ohio State University, Columbus, OH 43210.

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W. W. Muir III From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine (Hinchcliff, McKeever, Muir), and Department of Exercise Physiology, School of Health, Physical Education, and Recreation (Cooley, Lamb), The Ohio State University, Columbus, OH 43210.

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Summary

Effects of furosemide administration on exertion-induced changes in plasma renin activity and plasma concentrations of atrial natriuretic peptide and aldosterone in horses during sustained submaximal exertion were examined. Furosemide (1 mg/kg of body weight) or heparinized saline solution was administered iv to each of 6 mares not conditioned to exercise, either 4 hours or 2 minutes before 60 minutes of sustained submaximal running on a treadmill. Horses ran at a speed that induced heart rate approximately 65% of maximal after saline treatment. After 15 minutes of running, furosemide suppressed the exertion-induced increase in plasma concentrations of atrial natriuretic peptide (mean [95% confidence interval] values of 63.9 [9.9 to 421] pg/ml vs 100 [15.4 to 652] pg/ml after furosemide or saline treatment, respectively), and enhanced the response of plasma renin activity to exertion (18.6 [5.7 to 60.4] ng/ml/h vs 6.0 [1.8 to 19.4] ng/ml/h, respectively). An effect of furosemide on the exertion-induced increase in plasma aldosterone concentration was not detected.

Summary

Effects of furosemide administration on exertion-induced changes in plasma renin activity and plasma concentrations of atrial natriuretic peptide and aldosterone in horses during sustained submaximal exertion were examined. Furosemide (1 mg/kg of body weight) or heparinized saline solution was administered iv to each of 6 mares not conditioned to exercise, either 4 hours or 2 minutes before 60 minutes of sustained submaximal running on a treadmill. Horses ran at a speed that induced heart rate approximately 65% of maximal after saline treatment. After 15 minutes of running, furosemide suppressed the exertion-induced increase in plasma concentrations of atrial natriuretic peptide (mean [95% confidence interval] values of 63.9 [9.9 to 421] pg/ml vs 100 [15.4 to 652] pg/ml after furosemide or saline treatment, respectively), and enhanced the response of plasma renin activity to exertion (18.6 [5.7 to 60.4] ng/ml/h vs 6.0 [1.8 to 19.4] ng/ml/h, respectively). An effect of furosemide on the exertion-induced increase in plasma aldosterone concentration was not detected.

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