Effect of succinylcholine, diazepam, and dantrolene on the urethral pressure profile of anesthetized, healthy, sexually intact male cats

Ingrid M. Straeter-Knowlen From the Departments of Veterinary Clinical Sciences (Straeter-Knowlen, Knowlen, Marks) and Veterinary and Comparative Anatomy, Pharmacology, and Physiology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164, and the Tierärztliche Hochschule Hannover, Hannover, Germany (Wirth).

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 Dr med vet
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Steven L. Marks From the Departments of Veterinary Clinical Sciences (Straeter-Knowlen, Knowlen, Marks) and Veterinary and Comparative Anatomy, Pharmacology, and Physiology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164, and the Tierärztliche Hochschule Hannover, Hannover, Germany (Wirth).

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Robert C. Speth From the Departments of Veterinary Clinical Sciences (Straeter-Knowlen, Knowlen, Marks) and Veterinary and Comparative Anatomy, Pharmacology, and Physiology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164, and the Tierärztliche Hochschule Hannover, Hannover, Germany (Wirth).

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W. Wirth From the Departments of Veterinary Clinical Sciences (Straeter-Knowlen, Knowlen, Marks) and Veterinary and Comparative Anatomy, Pharmacology, and Physiology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164, and the Tierärztliche Hochschule Hannover, Hannover, Germany (Wirth).

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Grant G. Knowlen From the Departments of Veterinary Clinical Sciences (Straeter-Knowlen, Knowlen, Marks) and Veterinary and Comparative Anatomy, Pharmacology, and Physiology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164, and the Tierärztliche Hochschule Hannover, Hannover, Germany (Wirth).

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 DVM, PhD

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Summary

Effects of the neuromuscular blocking agent succinylcholine (n = 9), the centrally acting skeletal muscle relaxant diazepam (n = 11), and the direct-acting skeletal muscle relaxant dantrolene sodium (n = 8) on the urethral pressure profile were evaluated in anesthetized, healthy, sexually intact, adult male cats. Intravenous administration of succinylcholine (0.075 mg/kg of body weight) significantly decreased mean absolute pressure in the prostatic and post-prostatic/penile intraurethral segments by −9.5 and −6.5 mm of Hg, respectively (P = 0.0002 and P = 0.0006, respectively). Dantrolene (1.0 mg/kg, iv) significantly decreased mean prostatic and postprostatic/penile intraurethral segmental pressures by −3.5 and −2.8 mm of Hg, respectively (P = 0.005 and P = 0.0181, respectively). Diazepam (0.8 mg/kg, iv) did not significantly alter mean intraurethral segmental pressures. None of the drugs caused a change in segmental lengths of the urethra. These results indicate that skeletal muscle makes a substantial contribution to intraurethral tone in anesthetized, healthy, sexually intact male cats and that skeletal muscle relaxation may be successful in reducing prostatic and post-prostatic/penile urethral segmental tone in male cats. These results also suggest that dantrolene sodium may be valuable for the pharmacologic management of urethral disorders in male cats.

Summary

Effects of the neuromuscular blocking agent succinylcholine (n = 9), the centrally acting skeletal muscle relaxant diazepam (n = 11), and the direct-acting skeletal muscle relaxant dantrolene sodium (n = 8) on the urethral pressure profile were evaluated in anesthetized, healthy, sexually intact, adult male cats. Intravenous administration of succinylcholine (0.075 mg/kg of body weight) significantly decreased mean absolute pressure in the prostatic and post-prostatic/penile intraurethral segments by −9.5 and −6.5 mm of Hg, respectively (P = 0.0002 and P = 0.0006, respectively). Dantrolene (1.0 mg/kg, iv) significantly decreased mean prostatic and postprostatic/penile intraurethral segmental pressures by −3.5 and −2.8 mm of Hg, respectively (P = 0.005 and P = 0.0181, respectively). Diazepam (0.8 mg/kg, iv) did not significantly alter mean intraurethral segmental pressures. None of the drugs caused a change in segmental lengths of the urethra. These results indicate that skeletal muscle makes a substantial contribution to intraurethral tone in anesthetized, healthy, sexually intact male cats and that skeletal muscle relaxation may be successful in reducing prostatic and post-prostatic/penile urethral segmental tone in male cats. These results also suggest that dantrolene sodium may be valuable for the pharmacologic management of urethral disorders in male cats.

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