Effect of isoflurane on hematologic variables in ferrets

Robert P. Marini From the Division of Comparative Medicine, Massachusetts Institute of Technology, 37 Vassar St, Cambridge, MA 02139.

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Lynn R Jackson From the Division of Comparative Medicine, Massachusetts Institute of Technology, 37 Vassar St, Cambridge, MA 02139.

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Maria I. Esteves From the Division of Comparative Medicine, Massachusetts Institute of Technology, 37 Vassar St, Cambridge, MA 02139.

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Karl A. Andrutis From the Division of Comparative Medicine, Massachusetts Institute of Technology, 37 Vassar St, Cambridge, MA 02139.

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Carol M. Goslant From the Division of Comparative Medicine, Massachusetts Institute of Technology, 37 Vassar St, Cambridge, MA 02139.

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James G. Fox From the Division of Comparative Medicine, Massachusetts Institute of Technology, 37 Vassar St, Cambridge, MA 02139.

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Summary

Effects of isoflurane on the cbc in ferrets were studied. There was rapid decrease in all hematologic variables after induction of anesthesia. Percentage reductions in indices of the erythron (hematocrit, rbc count, hemoglobin concentration) exceeded those of plasma protein concentration and wbc count at the first postinduction time point. There was little additional decrease in these variables for the duration of anesthesia. The values had partially recovered to preanesthetic baseline at 45 minutes after anesthesia. Although these alterations appear to be well tolerated in healthy ferrets, care should be exercised when subjecting anemic, geriatric, or debilitated ferrets to isoflurane-induced anesthesia.

Summary

Effects of isoflurane on the cbc in ferrets were studied. There was rapid decrease in all hematologic variables after induction of anesthesia. Percentage reductions in indices of the erythron (hematocrit, rbc count, hemoglobin concentration) exceeded those of plasma protein concentration and wbc count at the first postinduction time point. There was little additional decrease in these variables for the duration of anesthesia. The values had partially recovered to preanesthetic baseline at 45 minutes after anesthesia. Although these alterations appear to be well tolerated in healthy ferrets, care should be exercised when subjecting anemic, geriatric, or debilitated ferrets to isoflurane-induced anesthesia.

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