Effect of estradiol administration and subsequent nonfeeding on liver estrogen receptor, serum apolipoprotein B-100, and serum triglycerides concentrations in steers

Norio Katoh From Hokkaido Branch Laboratory, National Institute of Animal Health (Katoh), Hitsujigaoka 4, Sapporo 062, Aichi Nishimikawa Livestock Hygiene Service Center (Minoura), Okazaki, Aichi 444, and the Department of Veterinary Internal Medicine, Rakuno Gakuen University (Uchida, Takahashi), Ebetsu 069, Japan.

Search for other papers by Norio Katoh in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
,
Seijiro Minoura From Hokkaido Branch Laboratory, National Institute of Animal Health (Katoh), Hitsujigaoka 4, Sapporo 062, Aichi Nishimikawa Livestock Hygiene Service Center (Minoura), Okazaki, Aichi 444, and the Department of Veterinary Internal Medicine, Rakuno Gakuen University (Uchida, Takahashi), Ebetsu 069, Japan.

Search for other papers by Seijiro Minoura in
Current site
Google Scholar
PubMed
Close
 DVM
,
Eiji Uchida From Hokkaido Branch Laboratory, National Institute of Animal Health (Katoh), Hitsujigaoka 4, Sapporo 062, Aichi Nishimikawa Livestock Hygiene Service Center (Minoura), Okazaki, Aichi 444, and the Department of Veterinary Internal Medicine, Rakuno Gakuen University (Uchida, Takahashi), Ebetsu 069, Japan.

Search for other papers by Eiji Uchida in
Current site
Google Scholar
PubMed
Close
 DVM
, and
Kiyoshi Takahashi From Hokkaido Branch Laboratory, National Institute of Animal Health (Katoh), Hitsujigaoka 4, Sapporo 062, Aichi Nishimikawa Livestock Hygiene Service Center (Minoura), Okazaki, Aichi 444, and the Department of Veterinary Internal Medicine, Rakuno Gakuen University (Uchida, Takahashi), Ebetsu 069, Japan.

Search for other papers by Kiyoshi Takahashi in
Current site
Google Scholar
PubMed
Close
 DVM, PhD

Click on author name to view affiliation information

Summary

Estradiol was administered to 3 steers (0.12 mg/kg of body weight/d for 14 consecutive days), followed by 2 days of nonfeeding (starvation). During estradiol administration, liver nuclear estrogen receptor and serum apolipoprotein B-100 (apoB-100), as well as serum triglycerides concentrations were increased, compared with values before administration. Starvation, together with interruption of estradiol administration, resulted in rapid decreases of the receptor, serum apoB-100, and serum triglycerides concentrations, and increase of nonesterified fatty acids concentration. Of the 3 steers, 2 had higher liver triglyceride content, compared with values before treatment. In the control group (3 steers that received vehicle alone, then starved similarly), these concentrations, except for serum nonesterified fatty acids and triglycerides concentrations after starvation, were not changed. In another experiment, serum apoB-100 concentration in dairy cows was significantly (P< 0.05) lower at parturition than values before and after parturition. These results indicate that estradiol may be involved in development of fatty liver in cattle.

Summary

Estradiol was administered to 3 steers (0.12 mg/kg of body weight/d for 14 consecutive days), followed by 2 days of nonfeeding (starvation). During estradiol administration, liver nuclear estrogen receptor and serum apolipoprotein B-100 (apoB-100), as well as serum triglycerides concentrations were increased, compared with values before administration. Starvation, together with interruption of estradiol administration, resulted in rapid decreases of the receptor, serum apoB-100, and serum triglycerides concentrations, and increase of nonesterified fatty acids concentration. Of the 3 steers, 2 had higher liver triglyceride content, compared with values before treatment. In the control group (3 steers that received vehicle alone, then starved similarly), these concentrations, except for serum nonesterified fatty acids and triglycerides concentrations after starvation, were not changed. In another experiment, serum apoB-100 concentration in dairy cows was significantly (P< 0.05) lower at parturition than values before and after parturition. These results indicate that estradiol may be involved in development of fatty liver in cattle.

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 40 40 12
PDF Downloads 34 34 2
Advertisement