Efficacy of albendazole against giardiasis in dogs

Stephen C. Barr From the Departments of Clinical Sciences (Barr, Heller, Erb) Microbiology, Immunology, and Parasitology (Bowman), College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

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 BVSc, PhD
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Dwight D. Bowman From the Departments of Clinical Sciences (Barr, Heller, Erb) Microbiology, Immunology, and Parasitology (Bowman), College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

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 PhD
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Ruth L. Heller From the Departments of Clinical Sciences (Barr, Heller, Erb) Microbiology, Immunology, and Parasitology (Bowman), College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

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Hollis N. Erb From the Departments of Clinical Sciences (Barr, Heller, Erb) Microbiology, Immunology, and Parasitology (Bowman), College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

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 DVM, PhD

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Summary

Efficacy of albendazole for treating giardiasis in dogs was assessed in 3 experiments. In experiment 1, Giardia cysts were cleared from feces of 5 of 7 dogs (as determined by the zinc-sulfate concentration technique) after the dogs received a single dose of albendazole (25 mg/kg of body weight, po), whereas feces of 3 of 7 dogs became clear of cysts without treatment. In experiment 2, feces of 5 of 5 dogs became clear of cysts after albendazole treatment (25 mg/kg, po, q 12 h for 4 doses); feces of 1 of 5 untreated control dogs became clear. In experiment 3, feces of 18 of 20 dogs became clear of cysts after albendazole (25 mg/kg, po, q 12 h for 4 doses) was given; none of the 20 control dogs had feces clear of cysts. Signs of toxicosis were not observed in any dog. These results indicate that a single dose of albendazole (25 mg/kg, po) is not effective for treating giardiasis in dogs. However, 4 doses of albendazole (25 mg/kg, po, q 12 h) are highly effective and nontoxic for treatment of giardiasis in dogs.

Summary

Efficacy of albendazole for treating giardiasis in dogs was assessed in 3 experiments. In experiment 1, Giardia cysts were cleared from feces of 5 of 7 dogs (as determined by the zinc-sulfate concentration technique) after the dogs received a single dose of albendazole (25 mg/kg of body weight, po), whereas feces of 3 of 7 dogs became clear of cysts without treatment. In experiment 2, feces of 5 of 5 dogs became clear of cysts after albendazole treatment (25 mg/kg, po, q 12 h for 4 doses); feces of 1 of 5 untreated control dogs became clear. In experiment 3, feces of 18 of 20 dogs became clear of cysts after albendazole (25 mg/kg, po, q 12 h for 4 doses) was given; none of the 20 control dogs had feces clear of cysts. Signs of toxicosis were not observed in any dog. These results indicate that a single dose of albendazole (25 mg/kg, po) is not effective for treating giardiasis in dogs. However, 4 doses of albendazole (25 mg/kg, po, q 12 h) are highly effective and nontoxic for treatment of giardiasis in dogs.

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