Pharmacokinetics of cefotaxime in neonatal pony foals

Sarah Y. Gardner From the Section of Medicine, Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348.

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Raymond W. Sweeney From the Section of Medicine, Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348.

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Thomas J. Divers From the Section of Medicine, Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348.

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Summary

Serum concentrations of cefotaxime and desacetylcefotaxime were measured in 1-week-old pony foals after iv administration of a single dose of cefotaxime.

The cefotaxime disposition data conformed to a two-compartment model with elimination half-life of 0.60 hour. The combined cefotaxime and desacetylcefotaxime data was best described by a four-compartment model. The apparent half-life describing the disappearance of desacetylcefotaxime was 1.69 hours.

Dosage of 40 mg/kg of body weight given iv every 4 to 6 hours for neonatal foals with gram-negative septicemia and every 2 hours for foals with meningitis is recommended for further study.

Summary

Serum concentrations of cefotaxime and desacetylcefotaxime were measured in 1-week-old pony foals after iv administration of a single dose of cefotaxime.

The cefotaxime disposition data conformed to a two-compartment model with elimination half-life of 0.60 hour. The combined cefotaxime and desacetylcefotaxime data was best described by a four-compartment model. The apparent half-life describing the disappearance of desacetylcefotaxime was 1.69 hours.

Dosage of 40 mg/kg of body weight given iv every 4 to 6 hours for neonatal foals with gram-negative septicemia and every 2 hours for foals with meningitis is recommended for further study.

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