Reduction of isoflurane anesthetic requirement by medetomidine and its restoration by atipamezole in dogs

Karin Kuersten Ewing From the Anesthesiology (Ewing, Short) and Epidemiology (Mohammed, Scarlett) Sections, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

Search for other papers by Karin Kuersten Ewing in
Current site
Google Scholar
PubMed
Close
 DVM, MSc
,
Hussni O. Mohammed From the Anesthesiology (Ewing, Short) and Epidemiology (Mohammed, Scarlett) Sections, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

Search for other papers by Hussni O. Mohammed in
Current site
Google Scholar
PubMed
Close
 BVSc, PhD
,
Janet M. Scarlett From the Anesthesiology (Ewing, Short) and Epidemiology (Mohammed, Scarlett) Sections, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

Search for other papers by Janet M. Scarlett in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
, and
Charles E. Short From the Anesthesiology (Ewing, Short) and Epidemiology (Mohammed, Scarlett) Sections, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

Search for other papers by Charles E. Short in
Current site
Google Scholar
PubMed
Close
 DVM, MS

Click on author name to view affiliation information

SUMMARY

The isoflurane-sparing effect of the α2-adrenergic agonist medetomidine (30 μg/kg of body weight, IV) was tested in 7 dogs, using a blinded, randomized-block study design. The baseline minimal alveolar concentration (mac) of isoflurane was 1.18 vol% (95% confidence interval [097,1.39])- Medetomidine significantly (P < 0.003) reduced isoflurane mac by 47.2%. Atipamezolc (0.3 mg/kg, iv), an α2-adrenergic antagonist, completely reversed the effect of mcdetomidine on isoflurane mac. Atipamezole alone did not significantly alter isoflurane mac.

After medetomidine administration, marked bradycardia developed in all dogs and persisted for more than 2 hours Mean arterial blood pressure increased acutely, but later decreased, and hypotension persisted for more than 2 hours. Atipamezole reversed the bradycardic and hypotensive effects of medetomidine.

Results of this study indicate that medetomidine mav be useful in clinical cases in which isoflurane mac-reduction is desirable and that atipamezole might be used to reverse desirable and undesirable effects of medetomidine during isoflurane anesthesia.

SUMMARY

The isoflurane-sparing effect of the α2-adrenergic agonist medetomidine (30 μg/kg of body weight, IV) was tested in 7 dogs, using a blinded, randomized-block study design. The baseline minimal alveolar concentration (mac) of isoflurane was 1.18 vol% (95% confidence interval [097,1.39])- Medetomidine significantly (P < 0.003) reduced isoflurane mac by 47.2%. Atipamezolc (0.3 mg/kg, iv), an α2-adrenergic antagonist, completely reversed the effect of mcdetomidine on isoflurane mac. Atipamezole alone did not significantly alter isoflurane mac.

After medetomidine administration, marked bradycardia developed in all dogs and persisted for more than 2 hours Mean arterial blood pressure increased acutely, but later decreased, and hypotension persisted for more than 2 hours. Atipamezole reversed the bradycardic and hypotensive effects of medetomidine.

Results of this study indicate that medetomidine mav be useful in clinical cases in which isoflurane mac-reduction is desirable and that atipamezole might be used to reverse desirable and undesirable effects of medetomidine during isoflurane anesthesia.

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 60 60 20
PDF Downloads 14 14 1
Advertisement