Pharmacokinetics of phenolsulfonphthalein in sheep

Terry J. Danielson From the Livestock Sciences Section, Agriculture Canada Research Station, PO Box 3000 Main, Lethbridge, Alberta, Canada T1J 4B1.

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Wesley G. Taylor From the Livestock Sciences Section, Agriculture Canada Research Station, PO Box 3000 Main, Lethbridge, Alberta, Canada T1J 4B1.

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Summary

Pharmacokinetic variables of phenolsulfonphthalein (psp) were determined in sheep after rapid iv injection and iv infusion to steady state. In Suffolk wethers, an average of < 75% of an iv administered dose was eliminated in urine, indicating that measures of systemic clearance overestimate renal clearance in this species. Furthermore, psp elimination from plasma was more rapid in Suffolk than Rambouillet wethers and, in Suffolk ewes, systemic clearance decreased from mean ± sd 7.8 ± 0.3 ml/min/kg of body weight to 4.7 ± 1.1 ml/min/kg at steady-state plasma concentration of 2.4 ± 0.3 and 151.3 ± 31.8 μg/ml, respectively. These observations indicate that, similar to that in other species, systemic clearance of psp in sheep is concentration-dependent and that significant differences may exist between breeds.

Summary

Pharmacokinetic variables of phenolsulfonphthalein (psp) were determined in sheep after rapid iv injection and iv infusion to steady state. In Suffolk wethers, an average of < 75% of an iv administered dose was eliminated in urine, indicating that measures of systemic clearance overestimate renal clearance in this species. Furthermore, psp elimination from plasma was more rapid in Suffolk than Rambouillet wethers and, in Suffolk ewes, systemic clearance decreased from mean ± sd 7.8 ± 0.3 ml/min/kg of body weight to 4.7 ± 1.1 ml/min/kg at steady-state plasma concentration of 2.4 ± 0.3 and 151.3 ± 31.8 μg/ml, respectively. These observations indicate that, similar to that in other species, systemic clearance of psp in sheep is concentration-dependent and that significant differences may exist between breeds.

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