Effect of ketoprofen on Escherichia coli heat-stable enterotoxin-induced diarrhea of calves

A. J. Roussel Jr. From the Departments of Large Animal Medicine and Surgery (Roussel, Dodson) and Veterinary Physiology and Pharmacology (Brumbaugh), Texas A&M University, College Station, TX 77843, the Department of Pathobiology (Sriranganathan), Virginia Tech, Blacksburg, VA 24061, and 3003 Jonesboro Rd, Abingdon, VA 24210 (Overbay).

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S. L. Dodson From the Departments of Large Animal Medicine and Surgery (Roussel, Dodson) and Veterinary Physiology and Pharmacology (Brumbaugh), Texas A&M University, College Station, TX 77843, the Department of Pathobiology (Sriranganathan), Virginia Tech, Blacksburg, VA 24061, and 3003 Jonesboro Rd, Abingdon, VA 24210 (Overbay).

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G. W. Brumbaugh From the Departments of Large Animal Medicine and Surgery (Roussel, Dodson) and Veterinary Physiology and Pharmacology (Brumbaugh), Texas A&M University, College Station, TX 77843, the Department of Pathobiology (Sriranganathan), Virginia Tech, Blacksburg, VA 24061, and 3003 Jonesboro Rd, Abingdon, VA 24210 (Overbay).

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N. Sriranganathan From the Departments of Large Animal Medicine and Surgery (Roussel, Dodson) and Veterinary Physiology and Pharmacology (Brumbaugh), Texas A&M University, College Station, TX 77843, the Department of Pathobiology (Sriranganathan), Virginia Tech, Blacksburg, VA 24061, and 3003 Jonesboro Rd, Abingdon, VA 24210 (Overbay).

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T. D. Overbay From the Departments of Large Animal Medicine and Surgery (Roussel, Dodson) and Veterinary Physiology and Pharmacology (Brumbaugh), Texas A&M University, College Station, TX 77843, the Department of Pathobiology (Sriranganathan), Virginia Tech, Blacksburg, VA 24061, and 3003 Jonesboro Rd, Abingdon, VA 24210 (Overbay).

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Summary

To evaluate the effect of ketoprofen on fecal output during secretory diarrhea, 16 calves were given approximately 200 μg of heat-stable Escherichia coli enterotoxin by suckling on 2 occasions. On one day, treatment was not administered. On the other day, either 3 mg of ketoprofen/kg of body weight (n = 8) or 6 mg of ketoprofen/kg (n = 8) was administered 1 hour before and 3 hours after administration of enterotoxin. Fecal output was no different after 8 or 24 hours from calves given 3 mg/kg, but fecal output was less at 8 hours and 24 hours for calves given 6 mg/kg (P = 0.0588), compared with the control day.

Summary

To evaluate the effect of ketoprofen on fecal output during secretory diarrhea, 16 calves were given approximately 200 μg of heat-stable Escherichia coli enterotoxin by suckling on 2 occasions. On one day, treatment was not administered. On the other day, either 3 mg of ketoprofen/kg of body weight (n = 8) or 6 mg of ketoprofen/kg (n = 8) was administered 1 hour before and 3 hours after administration of enterotoxin. Fecal output was no different after 8 or 24 hours from calves given 3 mg/kg, but fecal output was less at 8 hours and 24 hours for calves given 6 mg/kg (P = 0.0588), compared with the control day.

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