Pharmacokinetics of metronidazole after rectal administration in horses

Jenifer L. Garber From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Box 100136, Health Science Center, Gainesville, FL 32610-0136.

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Murray P. Brown From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Box 100136, Health Science Center, Gainesville, FL 32610-0136.

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Ronald R. Gronwall From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Box 100136, Health Science Center, Gainesville, FL 32610-0136.

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Kelly Merritt From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Box 100136, Health Science Center, Gainesville, FL 32610-0136.

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Summary

Five healthy adult mares and 1 gelding were given a single dose (15 mg/kg of body weight) of metronidazole per rectum. After manual evacuation of feces from the rectum, a suspension of crushed tablets and water (40 ml) was administered via a 28-F catheter advanced 30 cm into the rectum. Blood samples were obtained by jugular venipuncture, and metronidazole concentration was measured serially for the 14 hours after drug administration. Mean serum concentration of metronidazole peaked at 4.5 μg/ml, 0.83 hour after administration, and decreased to 0.38 μg/ml, 14 hours after administration. Mean elimination rate constant was 0.23/h, and the harmonic mean elimination half-life was 3.04 hours. Further study is necessary to determine a therapeutic dose regimen for metronidazole administered per rectum.

Summary

Five healthy adult mares and 1 gelding were given a single dose (15 mg/kg of body weight) of metronidazole per rectum. After manual evacuation of feces from the rectum, a suspension of crushed tablets and water (40 ml) was administered via a 28-F catheter advanced 30 cm into the rectum. Blood samples were obtained by jugular venipuncture, and metronidazole concentration was measured serially for the 14 hours after drug administration. Mean serum concentration of metronidazole peaked at 4.5 μg/ml, 0.83 hour after administration, and decreased to 0.38 μg/ml, 14 hours after administration. Mean elimination rate constant was 0.23/h, and the harmonic mean elimination half-life was 3.04 hours. Further study is necessary to determine a therapeutic dose regimen for metronidazole administered per rectum.

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