Tracheal mucociliary transport rate in awake dogs

Harry William Boothe From the Departments of Veterinary Small Animal Medicine and Surgery (HW Boothe) and Veterinary Physiology and Pharmacology (DM Boothe, Komkov, Hightower), College of Veterinary Medicine, and the Department of Statistics (Longnecker), College of Science, Texas A&M University, College Station, TX 77843.

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Dawn Merton Boothe From the Departments of Veterinary Small Animal Medicine and Surgery (HW Boothe) and Veterinary Physiology and Pharmacology (DM Boothe, Komkov, Hightower), College of Veterinary Medicine, and the Department of Statistics (Longnecker), College of Science, Texas A&M University, College Station, TX 77843.

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Andrea Komkov From the Departments of Veterinary Small Animal Medicine and Surgery (HW Boothe) and Veterinary Physiology and Pharmacology (DM Boothe, Komkov, Hightower), College of Veterinary Medicine, and the Department of Statistics (Longnecker), College of Science, Texas A&M University, College Station, TX 77843.

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Michaell T. Longnecker From the Departments of Veterinary Small Animal Medicine and Surgery (HW Boothe) and Veterinary Physiology and Pharmacology (DM Boothe, Komkov, Hightower), College of Veterinary Medicine, and the Department of Statistics (Longnecker), College of Science, Texas A&M University, College Station, TX 77843.

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Dan Hightower From the Departments of Veterinary Small Animal Medicine and Surgery (HW Boothe) and Veterinary Physiology and Pharmacology (DM Boothe, Komkov, Hightower), College of Veterinary Medicine, and the Department of Statistics (Longnecker), College of Science, Texas A&M University, College Station, TX 77843.

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Summary

To measure tracheal mucociliary transport rate (tmtr) in awake dogs, restrained in dorsal recumbency 99mtechnetium-labeled macroaggregated albumin was administered by tracheal injection, and the cephalic movement of boluses containing the radiopharmaceutical was detected by a gamma camera positioned lateral to the dog's head and neck. The distance traveled by each bolus was measured, relative to external markers placed a known distance apart. Tracheal mucociliary transport rates were calculated by dividing the measured distance of radiopharmaceutical movement by elapsed time. The technique was efficient and well tolerated. Mean (± sd) tmtr was 35.3 ± 15.9 mm/min. Significant (P = 0.029) difference in tmtr was found between males and females, but significant difference attributable to age of the dog was not detected. This method of measuring tmtr in awake dogs has potential for evaluation of clinical animal patients with suspected tracheal mucociliary abnormalities.

Summary

To measure tracheal mucociliary transport rate (tmtr) in awake dogs, restrained in dorsal recumbency 99mtechnetium-labeled macroaggregated albumin was administered by tracheal injection, and the cephalic movement of boluses containing the radiopharmaceutical was detected by a gamma camera positioned lateral to the dog's head and neck. The distance traveled by each bolus was measured, relative to external markers placed a known distance apart. Tracheal mucociliary transport rates were calculated by dividing the measured distance of radiopharmaceutical movement by elapsed time. The technique was efficient and well tolerated. Mean (± sd) tmtr was 35.3 ± 15.9 mm/min. Significant (P = 0.029) difference in tmtr was found between males and females, but significant difference attributable to age of the dog was not detected. This method of measuring tmtr in awake dogs has potential for evaluation of clinical animal patients with suspected tracheal mucociliary abnormalities.

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