Effects of orally administered prednisone on glucose tolerance and insulin secretion in clinically normal dogs

George E. Moore From the Departments of Physiology and Pharmacology, and Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.

Search for other papers by George E. Moore in
Current site
Google Scholar
PubMed
Close
 DVM, MS
and
Margarethe Hoenig From the Departments of Physiology and Pharmacology, and Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.

Search for other papers by Margarethe Hoenig in
Current site
Google Scholar
PubMed
Close
 Dr med vet, PhD

Click on author name to view affiliation information

SUMMARY

Prednisone was administered orally for 4 weeks at a dosage of 1.1 mg/kg of body weight/d, in divided dose every 12 hours, to a group of healthy adult dogs (n = 12). Intravenous glucose tolerance testing was performed before and after the 28-day regimen in each dog, as well as in dogs of a control group (n = 6). Glucose metabolism was evaluated by measurement of preprandial plasma insulin and glucose concentrations, total insulin secretion, and fractional clearance of glucose.

Mean preprandial plasma insulin and glucose concentrations were not increased after the 4-week regimen of prednisone. Total insulin secretion in response to an IV administered glucose load was not increased in treated dogs, compared with pretreatment values or with values for control dogs. The fractional clearance of glucose was also not altered in dogs given prednisone. Results indicate that anti-inflammatory doses of prednisone, given orally for 4 weeks, probably do not alter insulin sensitivity or glucose tolerance in clinically normal dogs.

SUMMARY

Prednisone was administered orally for 4 weeks at a dosage of 1.1 mg/kg of body weight/d, in divided dose every 12 hours, to a group of healthy adult dogs (n = 12). Intravenous glucose tolerance testing was performed before and after the 28-day regimen in each dog, as well as in dogs of a control group (n = 6). Glucose metabolism was evaluated by measurement of preprandial plasma insulin and glucose concentrations, total insulin secretion, and fractional clearance of glucose.

Mean preprandial plasma insulin and glucose concentrations were not increased after the 4-week regimen of prednisone. Total insulin secretion in response to an IV administered glucose load was not increased in treated dogs, compared with pretreatment values or with values for control dogs. The fractional clearance of glucose was also not altered in dogs given prednisone. Results indicate that anti-inflammatory doses of prednisone, given orally for 4 weeks, probably do not alter insulin sensitivity or glucose tolerance in clinically normal dogs.

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 45 45 21
PDF Downloads 28 28 7
Advertisement