Effects of exercise stress on various immune functions in horses

C. W. Wong From the Departments of Companion Animal Medicine and Surgery, (Wong, Thornton) and Parasitology (Opdebeeck), University of Queensland, Queensland, Australia, 4072, and Immunobiology Laboratory, Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Queensland, Australia, 4101 (Smith, Thong).

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S. E. Smith From the Departments of Companion Animal Medicine and Surgery, (Wong, Thornton) and Parasitology (Opdebeeck), University of Queensland, Queensland, Australia, 4072, and Immunobiology Laboratory, Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Queensland, Australia, 4101 (Smith, Thong).

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Y. H. Thong From the Departments of Companion Animal Medicine and Surgery, (Wong, Thornton) and Parasitology (Opdebeeck), University of Queensland, Queensland, Australia, 4072, and Immunobiology Laboratory, Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Queensland, Australia, 4101 (Smith, Thong).

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J. P. Opdebeeck From the Departments of Companion Animal Medicine and Surgery, (Wong, Thornton) and Parasitology (Opdebeeck), University of Queensland, Queensland, Australia, 4072, and Immunobiology Laboratory, Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Queensland, Australia, 4101 (Smith, Thong).

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J. R. Thornton From the Departments of Companion Animal Medicine and Surgery, (Wong, Thornton) and Parasitology (Opdebeeck), University of Queensland, Queensland, Australia, 4072, and Immunobiology Laboratory, Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Queensland, Australia, 4101 (Smith, Thong).

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Summary

Chemotactic locomotion and luminol-dependent chemiluminescence of neutrophils, mitogen-induced lymphocyte blastogenesis, serum cortisol concentration, immunoglobulin quantification, and leukocyte counts were determined to evaluate the effect of a single strenuous exercise in horses. Increased serum cortisol concentration (P < 0.01) and an increased neutrophil-to-lymphocyte ratio (P < 0.05) indicated that horses had been stressed. The chemotactic index and peak chemiluminescence production decreased significantly (P < 0.05 and P < 0.01, respectively) 1 day after exercise. Mitogen-induced blastogenesis of lymphocytes and serum immunoglobulin values remained unchanged in response to exercise. Results of this study indicated that a single bout of exercise may transiently impair neutrophil antimicrobial functions and nonspecific defense mechanisms, but not specific immunity in horses.

Summary

Chemotactic locomotion and luminol-dependent chemiluminescence of neutrophils, mitogen-induced lymphocyte blastogenesis, serum cortisol concentration, immunoglobulin quantification, and leukocyte counts were determined to evaluate the effect of a single strenuous exercise in horses. Increased serum cortisol concentration (P < 0.01) and an increased neutrophil-to-lymphocyte ratio (P < 0.05) indicated that horses had been stressed. The chemotactic index and peak chemiluminescence production decreased significantly (P < 0.05 and P < 0.01, respectively) 1 day after exercise. Mitogen-induced blastogenesis of lymphocytes and serum immunoglobulin values remained unchanged in response to exercise. Results of this study indicated that a single bout of exercise may transiently impair neutrophil antimicrobial functions and nonspecific defense mechanisms, but not specific immunity in horses.

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