Efficacy of a chewable formulation of ivermectin against a mixed infection of Ancylostoma braziliense and Ancylostoma tubaeforme in cats

Thomas J. Nolan From the Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 (Nolan, Niamatali, Bhopale, Schad) and Merck Sharp & Dohme Research Laboratories, PO Box 2000, Rahway, NJ 07065 (Longhofer).

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Susan Niamatali From the Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 (Nolan, Niamatali, Bhopale, Schad) and Merck Sharp & Dohme Research Laboratories, PO Box 2000, Rahway, NJ 07065 (Longhofer).

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Veena Bhopale From the Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 (Nolan, Niamatali, Bhopale, Schad) and Merck Sharp & Dohme Research Laboratories, PO Box 2000, Rahway, NJ 07065 (Longhofer).

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Susan L. Longhofer From the Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 (Nolan, Niamatali, Bhopale, Schad) and Merck Sharp & Dohme Research Laboratories, PO Box 2000, Rahway, NJ 07065 (Longhofer).

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Gerhard A. Schad From the Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 (Nolan, Niamatali, Bhopale, Schad) and Merck Sharp & Dohme Research Laboratories, PO Box 2000, Rahway, NJ 07065 (Longhofer).

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Summary

The efficacy of a beef-based, chewable formulation of ivermectin against a mixed infection of Ancylostoma braziliense and A tubaeforme was determined in cats. Ivermectin administered orally at approximately 24 μg/kg of body weight was 92.8% effective against adult A braziliense and 90.7% effective against adult A tubaeforme. The number of eggs per gram of feces had decreased 98.1% by 7 days after treatment. Clinical signs of hookworm disease also decreased after treatment. Location of adult parasites within the small intestine, percentage of infecting larvae that developed to the adult stage, and egg size in cats with infections of A braziliense and A tubaeforme were similar to those reported for cats with separate infections of either species.

Summary

The efficacy of a beef-based, chewable formulation of ivermectin against a mixed infection of Ancylostoma braziliense and A tubaeforme was determined in cats. Ivermectin administered orally at approximately 24 μg/kg of body weight was 92.8% effective against adult A braziliense and 90.7% effective against adult A tubaeforme. The number of eggs per gram of feces had decreased 98.1% by 7 days after treatment. Clinical signs of hookworm disease also decreased after treatment. Location of adult parasites within the small intestine, percentage of infecting larvae that developed to the adult stage, and egg size in cats with infections of A braziliense and A tubaeforme were similar to those reported for cats with separate infections of either species.

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