Efficacy of orally administered moxidectin against naturally acquired gastrointestinal nematodes in cattle

Gary L. Zimmerman From the College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 (Zimmerman, Hoberg) and American Cyanamid Co, PO Box 400, Princeton, NJ 08540 (Pankavich).

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Eric P. Hoberg From the College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 (Zimmerman, Hoberg) and American Cyanamid Co, PO Box 400, Princeton, NJ 08540 (Pankavich).

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John A. Pankavich From the College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 (Zimmerman, Hoberg) and American Cyanamid Co, PO Box 400, Princeton, NJ 08540 (Pankavich).

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Summary

Anthelmintic efficacy of moxidectin, an experimental antiparasitic macrocyclic lactone, was evaluated in a group of 15 calves harboring naturally acquired gastrointestinal nematodes. Three groups of 5 calves each served as untreated controls (group 1) or principals that were given moxidectin po at the rate of 0.2 mg/kg (group 2) or 0.4 mg/kg (group 3) of body weight. Equal numbers of control and treated calves were necropsied for parasite recovery on days 10 (3 control and 3 of each treatment group) and 11 (2 control and 2 of each treatment group) after treatment. Efficacies at both doses were > 99.8 and 99.9% against active and inhibited larvae and adults of Ostertagia spp, respectively. The overall mean efficacy of each dose was > 99.9%.

Summary

Anthelmintic efficacy of moxidectin, an experimental antiparasitic macrocyclic lactone, was evaluated in a group of 15 calves harboring naturally acquired gastrointestinal nematodes. Three groups of 5 calves each served as untreated controls (group 1) or principals that were given moxidectin po at the rate of 0.2 mg/kg (group 2) or 0.4 mg/kg (group 3) of body weight. Equal numbers of control and treated calves were necropsied for parasite recovery on days 10 (3 control and 3 of each treatment group) and 11 (2 control and 2 of each treatment group) after treatment. Efficacies at both doses were > 99.8 and 99.9% against active and inhibited larvae and adults of Ostertagia spp, respectively. The overall mean efficacy of each dose was > 99.9%.

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