Effects of Ehrlichia phagocytophila infection on serum thyroid hormone concentrations and on antipyrine clearance and metabolite formation in dwarf goats

Veronica N. Offiah From the Department of Veterinary Pharmacology, Pharmacy, and Toxicology, Faculty of Veterinary Medicine, State University of Utrecht, PO Box 80.176, 3508 TD Utrecht, the Netherlands.

Search for other papers by Veronica N. Offiah in
Current site
Google Scholar
PubMed
Close
 PhD
,
Sandra M. Nijmeijer From the Department of Veterinary Pharmacology, Pharmacy, and Toxicology, Faculty of Veterinary Medicine, State University of Utrecht, PO Box 80.176, 3508 TD Utrecht, the Netherlands.

Search for other papers by Sandra M. Nijmeijer in
Current site
Google Scholar
PubMed
Close
,
Cock T. M. van Duin From the Department of Veterinary Pharmacology, Pharmacy, and Toxicology, Faculty of Veterinary Medicine, State University of Utrecht, PO Box 80.176, 3508 TD Utrecht, the Netherlands.

Search for other papers by Cock T. M. van Duin in
Current site
Google Scholar
PubMed
Close
,
Renger F. Witkamp From the Department of Veterinary Pharmacology, Pharmacy, and Toxicology, Faculty of Veterinary Medicine, State University of Utrecht, PO Box 80.176, 3508 TD Utrecht, the Netherlands.

Search for other papers by Renger F. Witkamp in
Current site
Google Scholar
PubMed
Close
 MSc
, and
Adelbert S. J. P. A. M. van Miert From the Department of Veterinary Pharmacology, Pharmacy, and Toxicology, Faculty of Veterinary Medicine, State University of Utrecht, PO Box 80.176, 3508 TD Utrecht, the Netherlands.

Search for other papers by Adelbert S. J. P. A. M. van Miert in
Current site
Google Scholar
PubMed
Close
 DVM, PhD

Click on author name to view affiliation information

Summary

The influence of infection with Ehrlichia phagocytophila (ep) on serum thyroid hormone concentrations and on antipyrine (25 mg/kg of body weight, iv) plasma elimination and urinary metabolite excretion was studied in castrated male dwarf goats. Mean thyroid hormone concentrations moderately decreased in ep-infected goats, with maximal decrease in total and free triiodothyronine and thyroxine serum concentrations of 56, 64, 23, and 19%, respectively. The estimated pharmacokinetic values of antipyrine (ap) in ep-infected goats were similar to those in the goats when healthy. However, glucuronidation of the ap-metabolites 3-hydroxymethyl-ap, 4,4′-dihydroxy-ap, and 4-hydroxy-ap was reduced during the febrile episode of the acute-phase response to ep infection.

Summary

The influence of infection with Ehrlichia phagocytophila (ep) on serum thyroid hormone concentrations and on antipyrine (25 mg/kg of body weight, iv) plasma elimination and urinary metabolite excretion was studied in castrated male dwarf goats. Mean thyroid hormone concentrations moderately decreased in ep-infected goats, with maximal decrease in total and free triiodothyronine and thyroxine serum concentrations of 56, 64, 23, and 19%, respectively. The estimated pharmacokinetic values of antipyrine (ap) in ep-infected goats were similar to those in the goats when healthy. However, glucuronidation of the ap-metabolites 3-hydroxymethyl-ap, 4,4′-dihydroxy-ap, and 4-hydroxy-ap was reduced during the febrile episode of the acute-phase response to ep infection.

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 46 46 15
PDF Downloads 32 32 2
Advertisement