Effects of triiodothyronine treatment on pharmacokinetic properties and metabolite formation of antipyrine in dwarf goats

Veronica N. Offiah From the Department of Veterinary Pharmacology, Pharmacy, and Toxicology; Faculty of Veterinary Medicine; State University of Utrecht, PO Box 80.176, 3508 TD Utrecht, the Netherlands.

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Sandra M. Nijmeijer From the Department of Veterinary Pharmacology, Pharmacy, and Toxicology; Faculty of Veterinary Medicine; State University of Utrecht, PO Box 80.176, 3508 TD Utrecht, the Netherlands.

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Cock T. M. van Duin From the Department of Veterinary Pharmacology, Pharmacy, and Toxicology; Faculty of Veterinary Medicine; State University of Utrecht, PO Box 80.176, 3508 TD Utrecht, the Netherlands.

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Renger F. Witkamp From the Department of Veterinary Pharmacology, Pharmacy, and Toxicology; Faculty of Veterinary Medicine; State University of Utrecht, PO Box 80.176, 3508 TD Utrecht, the Netherlands.

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Adelbert S. J. P. A. M. van Miert From the Department of Veterinary Pharmacology, Pharmacy, and Toxicology; Faculty of Veterinary Medicine; State University of Utrecht, PO Box 80.176, 3508 TD Utrecht, the Netherlands.

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 DVM, PhD

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Summary

The influence of triiodothyronine (5 μg/kg of body weight, sc, q 12 h for 7 days) on antipyrine (ap, 25 mg/kg, iv) plasma elimination and urinary metabolite excretion was studied in castrated male dwarf goats. After triiodothyronine treatment, a significant increase in ap elimination was found. However, the observed changes in clearances for production of ap metabolites (nor-ap, 3-hydroxymethyl-ap; 4-hydroxy-ap, and 4,4′-dihydroxy-ap) do not suggest a clear selectivity of triiodothyronine toward any of the metabolic pathways of ap.

Summary

The influence of triiodothyronine (5 μg/kg of body weight, sc, q 12 h for 7 days) on antipyrine (ap, 25 mg/kg, iv) plasma elimination and urinary metabolite excretion was studied in castrated male dwarf goats. After triiodothyronine treatment, a significant increase in ap elimination was found. However, the observed changes in clearances for production of ap metabolites (nor-ap, 3-hydroxymethyl-ap; 4-hydroxy-ap, and 4,4′-dihydroxy-ap) do not suggest a clear selectivity of triiodothyronine toward any of the metabolic pathways of ap.

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