Effects of prostaglandin F2α and leukotriene D4 on pupil size, intraocular pressure, and blood-aqueous barrier in dogs
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Summary
In each of 5 groups of dogs, 0.05 ml of 1 of the following solutions was injected into the anterior chamber of both eyes: phosphate-buffered saline solution, 0.001 μg of prostaglandin F2α (pgf2α), 0.01 μg of pgf2α, 0.1 μg of leukotriene D4(ltd4), and 1 μg of ltd4. A 10% solution of sodium fluorescein was injected iv (14 mg/kg of body weight) at the same time, and pupil size, intraocular pressure, and anterior chamber fluorescence were measured for 1 hour after injections. In a dose-dependent manner, pgf2α was a potent miotic. A significant effect on intraocular pressure was not detected when the groups given pgf2α were compared with the control group. When compared with ltd4, pgf2α significantly (P < 0.05) increased the breakdown of the blood-aqueous barrier, as evidenced by increased fluorescein leakage into the anterior chamber. Leukotriene D4 caused a decrease in pupil size only at 5 minutes, compared with that of the control group. Intraocular pressure was greater (but not significantly) in the group given 1 μg of ltd4.
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