Effects of prostaglandin F and leukotriene D4 on pupil size, intraocular pressure, and blood-aqueous barrier in dogs

Joan Dziezyc From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine (Dziezyc, Millichamp, Keller) and the Department of Statistics, College of Science (Smith), Texas A&M University, College Station, TX 77843.

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Nicholas J. Millichamp From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine (Dziezyc, Millichamp, Keller) and the Department of Statistics, College of Science (Smith), Texas A&M University, College Station, TX 77843.

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Charlotte B. Keller From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine (Dziezyc, Millichamp, Keller) and the Department of Statistics, College of Science (Smith), Texas A&M University, College Station, TX 77843.

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William B. Smith From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine (Dziezyc, Millichamp, Keller) and the Department of Statistics, College of Science (Smith), Texas A&M University, College Station, TX 77843.

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Summary

In each of 5 groups of dogs, 0.05 ml of 1 of the following solutions was injected into the anterior chamber of both eyes: phosphate-buffered saline solution, 0.001 μg of prostaglandin F (pgf), 0.01 μg of pgf, 0.1 μg of leukotriene D4(ltd4), and 1 μg of ltd4. A 10% solution of sodium fluorescein was injected iv (14 mg/kg of body weight) at the same time, and pupil size, intraocular pressure, and anterior chamber fluorescence were measured for 1 hour after injections. In a dose-dependent manner, pgf was a potent miotic. A significant effect on intraocular pressure was not detected when the groups given pgf were compared with the control group. When compared with ltd4, pgf significantly (P < 0.05) increased the breakdown of the blood-aqueous barrier, as evidenced by increased fluorescein leakage into the anterior chamber. Leukotriene D4 caused a decrease in pupil size only at 5 minutes, compared with that of the control group. Intraocular pressure was greater (but not significantly) in the group given 1 μg of ltd4.

Summary

In each of 5 groups of dogs, 0.05 ml of 1 of the following solutions was injected into the anterior chamber of both eyes: phosphate-buffered saline solution, 0.001 μg of prostaglandin F (pgf), 0.01 μg of pgf, 0.1 μg of leukotriene D4(ltd4), and 1 μg of ltd4. A 10% solution of sodium fluorescein was injected iv (14 mg/kg of body weight) at the same time, and pupil size, intraocular pressure, and anterior chamber fluorescence were measured for 1 hour after injections. In a dose-dependent manner, pgf was a potent miotic. A significant effect on intraocular pressure was not detected when the groups given pgf were compared with the control group. When compared with ltd4, pgf significantly (P < 0.05) increased the breakdown of the blood-aqueous barrier, as evidenced by increased fluorescein leakage into the anterior chamber. Leukotriene D4 caused a decrease in pupil size only at 5 minutes, compared with that of the control group. Intraocular pressure was greater (but not significantly) in the group given 1 μg of ltd4.

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