Serum lipoprotein concentrations and hepatic lesions in obese cats undergoing weight loss

Donna S. Dimski From the Departments of Veterinary Clinical Sciences (Dimski, Buffington, Johnson, Sherding) and Veterinary Pathobiology (Rosol), College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp St, Columbus, OH 43210.

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C. A. Buffington From the Departments of Veterinary Clinical Sciences (Dimski, Buffington, Johnson, Sherding) and Veterinary Pathobiology (Rosol), College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp St, Columbus, OH 43210.

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Susan E. Johnson From the Departments of Veterinary Clinical Sciences (Dimski, Buffington, Johnson, Sherding) and Veterinary Pathobiology (Rosol), College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp St, Columbus, OH 43210.

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Robert G. Sherding From the Departments of Veterinary Clinical Sciences (Dimski, Buffington, Johnson, Sherding) and Veterinary Pathobiology (Rosol), College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp St, Columbus, OH 43210.

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Thomas J. Rosol From the Departments of Veterinary Clinical Sciences (Dimski, Buffington, Johnson, Sherding) and Veterinary Pathobiology (Rosol), College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp St, Columbus, OH 43210.

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Summary

Serum lipoprotein concentrations, routine serum biochemical values, and morphologic changes of the liver were evaluated in cats undergoing weight loss. Food was witheld from 6 obese and 6 control cats for 3 days (days 0 to 2), followed by feeding 50% of previous food intake for 26 days (days 3 to 28). Percutaneous liver biopsy specimens were obtained from all cats on days 0, 7, 14, and 28. Blood samples for serum biochemical analysis and lipoprotein profiles were obtained on days 0, 3, 7, 14, and 28. All cats lost weight throughout the study, and none developed signs of clinical illness, including those of idiopathic hepatic lipidosis syndrome. Serum total cholesterol concentrations decreased initially in all cats, but rapidly returned to normal after day 3 in obese cats, suggesting altered cholesterol metabolism during dietary restriction. Low-density lipoprotein concentrations decreased throughout the study in control cats, but were unchanged in obese cats. Examination of liver biopsy specimens from each cat revealed minimal lipid accumulation in all specimens, although some specimens contained hydropic degeneration.

Summary

Serum lipoprotein concentrations, routine serum biochemical values, and morphologic changes of the liver were evaluated in cats undergoing weight loss. Food was witheld from 6 obese and 6 control cats for 3 days (days 0 to 2), followed by feeding 50% of previous food intake for 26 days (days 3 to 28). Percutaneous liver biopsy specimens were obtained from all cats on days 0, 7, 14, and 28. Blood samples for serum biochemical analysis and lipoprotein profiles were obtained on days 0, 3, 7, 14, and 28. All cats lost weight throughout the study, and none developed signs of clinical illness, including those of idiopathic hepatic lipidosis syndrome. Serum total cholesterol concentrations decreased initially in all cats, but rapidly returned to normal after day 3 in obese cats, suggesting altered cholesterol metabolism during dietary restriction. Low-density lipoprotein concentrations decreased throughout the study in control cats, but were unchanged in obese cats. Examination of liver biopsy specimens from each cat revealed minimal lipid accumulation in all specimens, although some specimens contained hydropic degeneration.

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