Urethral pressure response to α-adrenergic agonist and antagonist drugs in anesthetized healthy male cats

Susan L. Frenier From the Department of Veterinary Clinical Medicine and Surgery (Frenier, Knowlen, Moore) and the Department of Veterinary and Comparative Anatomy, Physiology, and Pharmacology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164.

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Grant G. Knowlen From the Department of Veterinary Clinical Medicine and Surgery (Frenier, Knowlen, Moore) and the Department of Veterinary and Comparative Anatomy, Physiology, and Pharmacology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164.

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Robert C. Speth From the Department of Veterinary Clinical Medicine and Surgery (Frenier, Knowlen, Moore) and the Department of Veterinary and Comparative Anatomy, Physiology, and Pharmacology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164.

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Michael P. Moore From the Department of Veterinary Clinical Medicine and Surgery (Frenier, Knowlen, Moore) and the Department of Veterinary and Comparative Anatomy, Physiology, and Pharmacology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164.

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Summary

Urethral smooth muscle tone in response to treatment with phenylephrine, a selective α1-adrenergic receptor agonist, and prazosin a selective α1-adrenergic receptor antagonist, was evaluated in 12 anesthetized healthy adult sexually intact male cats. Intravenous administration of prazosin (20 to 30 μg/kg of body weight) decreased the average preprostatic and prostatic intraurethral pressure, compared with baseline and postphenylephrine (20 to 30 μg/kg) administration, values. Neither prazosin nor phenylephrine administration had an effect on functional urethral length. Results have implications for the pharmacologic management of lower urinary tract disorders in male cats.

Summary

Urethral smooth muscle tone in response to treatment with phenylephrine, a selective α1-adrenergic receptor agonist, and prazosin a selective α1-adrenergic receptor antagonist, was evaluated in 12 anesthetized healthy adult sexually intact male cats. Intravenous administration of prazosin (20 to 30 μg/kg of body weight) decreased the average preprostatic and prostatic intraurethral pressure, compared with baseline and postphenylephrine (20 to 30 μg/kg) administration, values. Neither prazosin nor phenylephrine administration had an effect on functional urethral length. Results have implications for the pharmacologic management of lower urinary tract disorders in male cats.

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