Relation of fructosamine to serum protein, albumin, and glucose concentrations in healthy and diabetic dogs

M. Kawamoto From the Departments of Clinical Pathology (Kawamoto, Kaneko), Physiological Sciences (Heusner), and Medicine (Feldman), School of Veterinary Medicine, University of California, Davis, CA 95616, and the Department of Biochemistry, Azabu University, Tokyo, Japan (Koizumi).

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J. J. Kaneko From the Departments of Clinical Pathology (Kawamoto, Kaneko), Physiological Sciences (Heusner), and Medicine (Feldman), School of Veterinary Medicine, University of California, Davis, CA 95616, and the Department of Biochemistry, Azabu University, Tokyo, Japan (Koizumi).

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A. A. Heusner From the Departments of Clinical Pathology (Kawamoto, Kaneko), Physiological Sciences (Heusner), and Medicine (Feldman), School of Veterinary Medicine, University of California, Davis, CA 95616, and the Department of Biochemistry, Azabu University, Tokyo, Japan (Koizumi).

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E. C. Feldman From the Departments of Clinical Pathology (Kawamoto, Kaneko), Physiological Sciences (Heusner), and Medicine (Feldman), School of Veterinary Medicine, University of California, Davis, CA 95616, and the Department of Biochemistry, Azabu University, Tokyo, Japan (Koizumi).

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I. Koizumi From the Departments of Clinical Pathology (Kawamoto, Kaneko), Physiological Sciences (Heusner), and Medicine (Feldman), School of Veterinary Medicine, University of California, Davis, CA 95616, and the Department of Biochemistry, Azabu University, Tokyo, Japan (Koizumi).

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Summary

The relation of the glycated serum protein, fructosamine, to serum protein, albumin, and glucose concentrations was examined in healthy dogs, dogs with hypo- or hyperproteinemia, and diabetic dogs. Fructosamine was determined by use of an adaptation of an automated kit method. The reference range for fructosamine in a composite group of control dogs was found to be 1.7 to 3.38 mmol/L (mean ± sd, 2.54 ± 0.42 mmol/L). Fructosamine was not correlated to serum total protein, but was highly correlated to albumin in dogs with hypoalbuminemia. To normalize the data with respect to albumin, it is suggested that the lower limit of the reference range for albumin concentration (2.5 g/dl) be used for adjustment of fructosamine concentration and only in hypoalbuminemic dogs. In 6 hyperglycemic diabetic dogs, fructosamine concentration was well above the reference range. It is concluded that although fructosamine may be a potentially useful guide to assess the average blood glucose concentration over the preceding few days in dogs, further study is required to establish its value as a guide to glucose control in diabetic dogs.

Summary

The relation of the glycated serum protein, fructosamine, to serum protein, albumin, and glucose concentrations was examined in healthy dogs, dogs with hypo- or hyperproteinemia, and diabetic dogs. Fructosamine was determined by use of an adaptation of an automated kit method. The reference range for fructosamine in a composite group of control dogs was found to be 1.7 to 3.38 mmol/L (mean ± sd, 2.54 ± 0.42 mmol/L). Fructosamine was not correlated to serum total protein, but was highly correlated to albumin in dogs with hypoalbuminemia. To normalize the data with respect to albumin, it is suggested that the lower limit of the reference range for albumin concentration (2.5 g/dl) be used for adjustment of fructosamine concentration and only in hypoalbuminemic dogs. In 6 hyperglycemic diabetic dogs, fructosamine concentration was well above the reference range. It is concluded that although fructosamine may be a potentially useful guide to assess the average blood glucose concentration over the preceding few days in dogs, further study is required to establish its value as a guide to glucose control in diabetic dogs.

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