Differential activity of cythioate against female and male Ctenocephalides felis on cats

Michael W. Dryden From the Department of Laboratory Medicine, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506.

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 DVM, PhD

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Summary

A study was conducted to determine whether cythioate, a systemically active insecticide, has different activity against male and female Ctenocephalides felis, the cat flea.

Eighteen cats were allotted equally to 1 control and 2 treatment groups and infested on day 0 with fixed ratios of male and female cat fleas. Cats in the untreated control group and treatment group 2 were infested with 50 fleas with a female-to-male ratio of approximately 2:1. Cats in treatment group 1 were infested with 50 fleas with a female-to-male ratio of 1:1. Cythioate was administered orally to cats in the treatment groups at the dosage of 3.6 mg/kg of body weight once daily on days 0 and 3. Fleas remaining after treatment were removed, sexed, and counted on day 5.

The efficacy of cythioate after 2 dosings was 82.8 and 33.4% against female and male fleas, respectively. The greater activity against female fleas resulted in posttreatment female-to-male ratios in treatment groups 1 and 2 of 0.32:1 and 0.54:1, respectively. Fleas recovered from untreated control cats had a final female-to-male ratio of 2.27:1. Total population control efficacies for treatment groups 1 and 2 were 61.7 and 67.6%, respectively.

Summary

A study was conducted to determine whether cythioate, a systemically active insecticide, has different activity against male and female Ctenocephalides felis, the cat flea.

Eighteen cats were allotted equally to 1 control and 2 treatment groups and infested on day 0 with fixed ratios of male and female cat fleas. Cats in the untreated control group and treatment group 2 were infested with 50 fleas with a female-to-male ratio of approximately 2:1. Cats in treatment group 1 were infested with 50 fleas with a female-to-male ratio of 1:1. Cythioate was administered orally to cats in the treatment groups at the dosage of 3.6 mg/kg of body weight once daily on days 0 and 3. Fleas remaining after treatment were removed, sexed, and counted on day 5.

The efficacy of cythioate after 2 dosings was 82.8 and 33.4% against female and male fleas, respectively. The greater activity against female fleas resulted in posttreatment female-to-male ratios in treatment groups 1 and 2 of 0.32:1 and 0.54:1, respectively. Fleas recovered from untreated control cats had a final female-to-male ratio of 2.27:1. Total population control efficacies for treatment groups 1 and 2 were 61.7 and 67.6%, respectively.

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