Efficacy of milbemycin oxime against naturally acquired or experimentally induced Ancylostoma spp and Trichuris vulpis infections in dogs

Byron L. Blagburn From the Department of Pathobiology (Blagburn, Hendrix, Lindsay, Vaughan, Wright), College of Veterinary Medicine, Auburn University, AL 36849-5519; and the Animal Health Division, CIBA-GEIGY Corp, Greensboro, NC 27419 (Hepler).

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Charles M. Hendrix From the Department of Pathobiology (Blagburn, Hendrix, Lindsay, Vaughan, Wright), College of Veterinary Medicine, Auburn University, AL 36849-5519; and the Animal Health Division, CIBA-GEIGY Corp, Greensboro, NC 27419 (Hepler).

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David S. Lindsay From the Department of Pathobiology (Blagburn, Hendrix, Lindsay, Vaughan, Wright), College of Veterinary Medicine, Auburn University, AL 36849-5519; and the Animal Health Division, CIBA-GEIGY Corp, Greensboro, NC 27419 (Hepler).

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Joy L. Vaughan From the Department of Pathobiology (Blagburn, Hendrix, Lindsay, Vaughan, Wright), College of Veterinary Medicine, Auburn University, AL 36849-5519; and the Animal Health Division, CIBA-GEIGY Corp, Greensboro, NC 27419 (Hepler).

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Douglas I. Hepler From the Department of Pathobiology (Blagburn, Hendrix, Lindsay, Vaughan, Wright), College of Veterinary Medicine, Auburn University, AL 36849-5519; and the Animal Health Division, CIBA-GEIGY Corp, Greensboro, NC 27419 (Hepler).

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James C. Wright From the Department of Pathobiology (Blagburn, Hendrix, Lindsay, Vaughan, Wright), College of Veterinary Medicine, Auburn University, AL 36849-5519; and the Animal Health Division, CIBA-GEIGY Corp, Greensboro, NC 27419 (Hepler).

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Summary

The efficacy of milbemycin oxime was evaluated at dosages of 0.25, 0.50 and 0.75 mg/kg of body weight in dogs naturally infected with mature Ancylostoma spp, at a dosage of 0.50 mg/kg in dogs with experimentally induced immature and mature A caninum, and at dosages of 0.55 to 0.86 mg/kg in dogs naturally infected with mature Trichuris vulpis. Milbemycin oxime was 95 and 99% effective against mature Ancylostoma spp at dosages of 0.50 and 0.75 mg/kg, respectively, but only 49% effective at a dosage of 0.25 mg/kg. Efficacy was 49% against pulmonary L3-L4 stages of A caninum (36 hours after inoculation), > 80% against L4 (120 hours after inoculation) and early L5 stages (216 hours after inoculation), and > 90% against experimentally induced mature stages (360 hours after inoculation). Milbemycin oxime was also 97% effective in the removal of mature Tr vulpis from naturally infected dogs. Adverse reactions were not observed following treatment in any of the dogs.

Summary

The efficacy of milbemycin oxime was evaluated at dosages of 0.25, 0.50 and 0.75 mg/kg of body weight in dogs naturally infected with mature Ancylostoma spp, at a dosage of 0.50 mg/kg in dogs with experimentally induced immature and mature A caninum, and at dosages of 0.55 to 0.86 mg/kg in dogs naturally infected with mature Trichuris vulpis. Milbemycin oxime was 95 and 99% effective against mature Ancylostoma spp at dosages of 0.50 and 0.75 mg/kg, respectively, but only 49% effective at a dosage of 0.25 mg/kg. Efficacy was 49% against pulmonary L3-L4 stages of A caninum (36 hours after inoculation), > 80% against L4 (120 hours after inoculation) and early L5 stages (216 hours after inoculation), and > 90% against experimentally induced mature stages (360 hours after inoculation). Milbemycin oxime was also 97% effective in the removal of mature Tr vulpis from naturally infected dogs. Adverse reactions were not observed following treatment in any of the dogs.

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