Effect of probenecid on the pharmacokinetics of flunixin meglumine and phenylbutazone in healthy mares

Juan Manuel L. Zertuche From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Box J-136 JHMHC, Gainesville, FL 32610-0136.

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Murray P. Brown From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Box J-136 JHMHC, Gainesville, FL 32610-0136.

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Ronald Gronwall From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Box J-136 JHMHC, Gainesville, FL 32610-0136.

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Kelly Merritt From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Box J-136 JHMHC, Gainesville, FL 32610-0136.

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Summary

Pharmacokinetic values for flunixin meglumine (1 mg/kg of body weight) and phenylbutazone (4 mg/kg) dosages were determined after a single iv injection with and without concurrent intragastric administration of probenecid (50 mg/kg) in 6 healthy mares. Significant difference was not apparent in the pharmacokinetic values of flunixin meglumine with and without concurrent probenecid administration. Significant (P ≤ 0.05) increase was evident in the 12-hour mean concentration of phenylbutazone (11.45 ± 1.66 μg/ml without probenecid; 14.56 ± 1.20 μg/ml with probenecid) along with significant (P ≤ 0.05) reduction in its volume of distribution at steady state associated with concurrent probenecid administration (218.6 ± 11.52 ml/kg without probenecid; 169.4 ± 9.25 ml/kg with probenecid).

Summary

Pharmacokinetic values for flunixin meglumine (1 mg/kg of body weight) and phenylbutazone (4 mg/kg) dosages were determined after a single iv injection with and without concurrent intragastric administration of probenecid (50 mg/kg) in 6 healthy mares. Significant difference was not apparent in the pharmacokinetic values of flunixin meglumine with and without concurrent probenecid administration. Significant (P ≤ 0.05) increase was evident in the 12-hour mean concentration of phenylbutazone (11.45 ± 1.66 μg/ml without probenecid; 14.56 ± 1.20 μg/ml with probenecid) along with significant (P ≤ 0.05) reduction in its volume of distribution at steady state associated with concurrent probenecid administration (218.6 ± 11.52 ml/kg without probenecid; 169.4 ± 9.25 ml/kg with probenecid).

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