Evaluation of a subunit vaccine for bovine adenovirus type 3

Ian A. York From the Department of Veterinary Microbiology and Immunology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, NIG 2W1 Canada.

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 DVM, MSc
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Jan Thorsen From the Department of Veterinary Microbiology and Immunology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, NIG 2W1 Canada.

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 DVM, PhD

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Summary

The hexon subunit of bovine adenovirus serotype 3 (bav-3) was purified by use of anion-exchange chromatography. A vaccine composed of the purified hexon in immune-stimulating complexes was administered and induced high titer of virus-neutralizing antibody in rabbits and calves.

Summary

The hexon subunit of bovine adenovirus serotype 3 (bav-3) was purified by use of anion-exchange chromatography. A vaccine composed of the purified hexon in immune-stimulating complexes was administered and induced high titer of virus-neutralizing antibody in rabbits and calves.

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