Estrogen and progesterone receptor status of mammary carcinomas and correlation with clinical outcome in dogs

Eva A. Sartin From the Department of Pathobiology (Sartin, Kwapien, and Wolfe), College of Veterinary Medicine, Auburn University, AL 36849-5519, and the Department of Pharmacology (Barnes), University of Alabama at Birmingham, Birmingham, AL 35294.

Search for other papers by Eva A. Sartin in
Current site
Google Scholar
PubMed Close
 DVM, PhD
,
Stephen Barnes From the Department of Pathobiology (Sartin, Kwapien, and Wolfe), College of Veterinary Medicine, Auburn University, AL 36849-5519, and the Department of Pharmacology (Barnes), University of Alabama at Birmingham, Birmingham, AL 35294.

Search for other papers by Stephen Barnes in
Current site
Google Scholar
PubMed Close
 PhD
,
Robert P. Kwapien From the Department of Pathobiology (Sartin, Kwapien, and Wolfe), College of Veterinary Medicine, Auburn University, AL 36849-5519, and the Department of Pharmacology (Barnes), University of Alabama at Birmingham, Birmingham, AL 35294.

Search for other papers by Robert P. Kwapien in
Current site
Google Scholar
PubMed Close
 DVM, PhD
, and
Lauren G. Wolfe From the Department of Pathobiology (Sartin, Kwapien, and Wolfe), College of Veterinary Medicine, Auburn University, AL 36849-5519, and the Department of Pharmacology (Barnes), University of Alabama at Birmingham, Birmingham, AL 35294.

Search for other papers by Lauren G. Wolfe in
Current site
Google Scholar
PubMed Close
 DVM, PhD
Free access

Summary

Estrogen and progesterone receptors (er, pr) were measured in cytosol fractions from 18 primary canine mammary carcinomas by use of biochemical assays. One or both receptors were detected (> 10 fmol/mg of cytosol protein) in 11 tumors: 5 er and pr; 2 er only; 4 pr only. Mean cytoplasmic receptor concentrations (fmol/mg of cytosol protein) were 22.8 ± 2.9 (sem) for er and 51.0 ± 10.3 for pr in tumors containing er and pr, 28.8 ± 12.1 for er in tumors containing only er and 13.2 ± 1.5 for pr in tumors containing only pr. Estrogen or progesterone receptors or both were identified in 6 of 9 tubular adenocarcinomas, 4 of 5 papillary adenocarcinomas, and 1 of 1 squamous cell carcinoma. These receptors were not identified in solid carcinomas (n = 2) or a single spindle cell carcinoma. Although the number of cases was limited, survival times of dogs tended to be longest in those with tumors containing er alone or in combination with pr, intermediate in those with tumors containing only pr, and shortest in those with tumors without er or pr. A correlation was not apparent between receptor status and age, presence of ovaries, tumor size, or histologic classification of the tumor. In the analysis of this series, the extent of surgery (mastectomy of the involved gland vs unilateral or bilateral mastectomy) did not appear to influence the outcome of the disease, and metastasis to regional lymph nodes did not appear to be a reliable prognostic indicator.

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 4125 4031 28
PDF Downloads 101 51 3
Cover American Journal of Veterinary Research
American Journal of Veterinary Research
Issue:
01 Nov 1992
Advertisement