Effect of the somatostatin analogue octreotide on gastric fluid pH in ponies

J. E. Sojka From the Department of Veterinary Clinical Studies (Sojka, Weiss) and Statistics (Samuels, You), Purdue University, West Lafayette, IN 47907.

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J. S. Weiss From the Department of Veterinary Clinical Studies (Sojka, Weiss) and Statistics (Samuels, You), Purdue University, West Lafayette, IN 47907.

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M. L. Samuels From the Department of Veterinary Clinical Studies (Sojka, Weiss) and Statistics (Samuels, You), Purdue University, West Lafayette, IN 47907.

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Guey-Mei You From the Department of Veterinary Clinical Studies (Sojka, Weiss) and Statistics (Samuels, You), Purdue University, West Lafayette, IN 47907.

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SUMMARY

The effect of the somatostatin analogue, octreotide, on gastric fluid pH was investigated in 4 ponies. Gastric fluid pH was determined after sc administration of octreotide or physiologic saline solution (control). A baseline sample of fluid was obtained, the agent was given, and 8 additional samples were collected hourly. Administration of octreotide at all dosages tested (0.1, 0.5, 1.0, and 5.0 μg/kg of body weight) increased gastric pH to > 5.0. Baseline values were consistently < 2.7. Administration of octreotide at these same dosages induced gastric pH values > 4.0 for 2.4 ± 1.2, 4.8 ± 0.8, 5.7 ± 1.3, and 5.4 ± 2.6 (mean ± sd) continuous hours, respectively. Treatment at all dosages increased the pH of gastric fluid, compared with control values. The duration of the increase in pH was significantly (P < 0.05) different than that of the control treatment, even for the lowest dosage, 0.1 μg/kg.

SUMMARY

The effect of the somatostatin analogue, octreotide, on gastric fluid pH was investigated in 4 ponies. Gastric fluid pH was determined after sc administration of octreotide or physiologic saline solution (control). A baseline sample of fluid was obtained, the agent was given, and 8 additional samples were collected hourly. Administration of octreotide at all dosages tested (0.1, 0.5, 1.0, and 5.0 μg/kg of body weight) increased gastric pH to > 5.0. Baseline values were consistently < 2.7. Administration of octreotide at these same dosages induced gastric pH values > 4.0 for 2.4 ± 1.2, 4.8 ± 0.8, 5.7 ± 1.3, and 5.4 ± 2.6 (mean ± sd) continuous hours, respectively. Treatment at all dosages increased the pH of gastric fluid, compared with control values. The duration of the increase in pH was significantly (P < 0.05) different than that of the control treatment, even for the lowest dosage, 0.1 μg/kg.

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