Evaluation of colostral IgGl absorption in newborn calves after treatment with alkalinizing agents

M. Wayne Ayers From the Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-7040.

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Thomas E. Besser From the Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-7040.

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Summary

The effects of alkalinizing agents, administered prior to feeding colostrum, on blood-gas and acid-base values and on absorption of IgGl were determined in 40 newborn Holstein calves. Two treatments, sodium bicarbonate (3 mEq/kg of body weight, IV) and doxapram HCl (2 mg/kg, IV), were evaluated, using a randomized complete-block experimental design. These treatments resulted in significant (P< 0.01) alteration of blood-gas and acid-base values, generally in the direction of normal values for adult cattle. Significant least squares mean effects were detected for sodium bicarbonate treatment on blood pH ( + 0.04 units, P < 0.01), Pco2( + 4.1 mm of Hg, P <0.01), and HCO3 concentration ( + 4.4 mEq/L, P < 0.01). Significant least squares mean effects were detected for doxapram HC1 treatment on blood pH ( + 0.06 pH units, P <0.01) and Pco2(–5.2 mm of Hg, P <0.01). Absorption of colostral IgGl was not affected by the treatments given or by the altered blood-gas and/or acid-base status.

Summary

The effects of alkalinizing agents, administered prior to feeding colostrum, on blood-gas and acid-base values and on absorption of IgGl were determined in 40 newborn Holstein calves. Two treatments, sodium bicarbonate (3 mEq/kg of body weight, IV) and doxapram HCl (2 mg/kg, IV), were evaluated, using a randomized complete-block experimental design. These treatments resulted in significant (P< 0.01) alteration of blood-gas and acid-base values, generally in the direction of normal values for adult cattle. Significant least squares mean effects were detected for sodium bicarbonate treatment on blood pH ( + 0.04 units, P < 0.01), Pco2( + 4.1 mm of Hg, P <0.01), and HCO3 concentration ( + 4.4 mEq/L, P < 0.01). Significant least squares mean effects were detected for doxapram HC1 treatment on blood pH ( + 0.06 pH units, P <0.01) and Pco2(–5.2 mm of Hg, P <0.01). Absorption of colostral IgGl was not affected by the treatments given or by the altered blood-gas and/or acid-base status.

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