Hematologic alterations in adult cats fed 6 or 12% propylene glycol

Milton C. Bauer From the Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Ave, St Paul, MN 55108.

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Douglas J. Weiss From the Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Ave, St Paul, MN 55108.

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Victor Perman From the Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Ave, St Paul, MN 55108.

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Summary

Cat foods containing propylene glycol (pg) induce Heinz body formation in feline erythrocytes. To further study the hematologic importance of dietary pg, 21 adult cats were allotted to 3 groups of 7 each and fed diets containing 0,6, or 12% pg on a dry-weight basis. Cats fed pg had a dose-related increase in Heinz bodies within 2 weeks, and the increase persisted throughout the study. Although only slight changes occurred in pcv, hemoglobin concentration, and rbc count, punctate reticulocytes were significantly increased in the group fed 12% pg. Mean rbc survival was decreased in the groups fed 6 or 12% pg by 30 and 55%, respectively, compared with the control group. These data indicate that pg-containing diets cause a dose-dependent erythrocyte destruction, even when fed at concentrations as low as 6%.

Summary

Cat foods containing propylene glycol (pg) induce Heinz body formation in feline erythrocytes. To further study the hematologic importance of dietary pg, 21 adult cats were allotted to 3 groups of 7 each and fed diets containing 0,6, or 12% pg on a dry-weight basis. Cats fed pg had a dose-related increase in Heinz bodies within 2 weeks, and the increase persisted throughout the study. Although only slight changes occurred in pcv, hemoglobin concentration, and rbc count, punctate reticulocytes were significantly increased in the group fed 12% pg. Mean rbc survival was decreased in the groups fed 6 or 12% pg by 30 and 55%, respectively, compared with the control group. These data indicate that pg-containing diets cause a dose-dependent erythrocyte destruction, even when fed at concentrations as low as 6%.

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