Evaluation of metoclopramide hydrochloride as an aid for passage of a flexible endoscope into the duodenum of dogs

William E. Monroe From the Departments of Small Animal Clinical Sciences (Monroe, Leib, Matz, Davenport) and Biomedical Sciences (Kenny), Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0442.

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Michael S. Leib From the Departments of Small Animal Clinical Sciences (Monroe, Leib, Matz, Davenport) and Biomedical Sciences (Kenny), Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0442.

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Michael E. Matz From the Departments of Small Animal Clinical Sciences (Monroe, Leib, Matz, Davenport) and Biomedical Sciences (Kenny), Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0442.

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Deborah J. Davenport From the Departments of Small Animal Clinical Sciences (Monroe, Leib, Matz, Davenport) and Biomedical Sciences (Kenny), Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0442.

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Laura P. Nelson From the Departments of Small Animal Clinical Sciences (Monroe, Leib, Matz, Davenport) and Biomedical Sciences (Kenny), Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0442.

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James E. Kenny From the Departments of Small Animal Clinical Sciences (Monroe, Leib, Matz, Davenport) and Biomedical Sciences (Kenny), Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0442.

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Summary

The purposes of this study were to evaluate the efficacy of metoclopramide to aid passage of a flexible endoscope into the duodenum of dogs, and to determine whether the effect of metoclopramide is dependent on dose. In a randomized, blinded, complete-block design, 6 healthy dogs were anesthetized, then each was given saline solution or 1 of 4 doses of metoclopramide on different days. The - ease of passage of a flexible, fiberoptic gastroscope through the pylorus was assessed independently by 3 endoscopists.

Administration of metoclopramide hydrochloride at a dosage of 0.4 mg/kg of body weight, iv, made passage of a flexible endoscope into the duodenum significantly (P= 0.009) more difficult than when, saline solution was administered; however, dosages of 0.1, 0.2 and 0.8 mg of metoclopramide/kg did not (P = 0.489, 0.842, and 0.092 respectively). It was concluded that metoclopramide did not facilitate, and at one dosage hindered, successful passage of a flexible endoscope into the duodenum of healthy dogs under the conditions of the study. Metoclopramide, therefore, cannot be recommended as an aid for passage of a flexible endoscope into the duodenum of dogs.

Summary

The purposes of this study were to evaluate the efficacy of metoclopramide to aid passage of a flexible endoscope into the duodenum of dogs, and to determine whether the effect of metoclopramide is dependent on dose. In a randomized, blinded, complete-block design, 6 healthy dogs were anesthetized, then each was given saline solution or 1 of 4 doses of metoclopramide on different days. The - ease of passage of a flexible, fiberoptic gastroscope through the pylorus was assessed independently by 3 endoscopists.

Administration of metoclopramide hydrochloride at a dosage of 0.4 mg/kg of body weight, iv, made passage of a flexible endoscope into the duodenum significantly (P= 0.009) more difficult than when, saline solution was administered; however, dosages of 0.1, 0.2 and 0.8 mg of metoclopramide/kg did not (P = 0.489, 0.842, and 0.092 respectively). It was concluded that metoclopramide did not facilitate, and at one dosage hindered, successful passage of a flexible endoscope into the duodenum of healthy dogs under the conditions of the study. Metoclopramide, therefore, cannot be recommended as an aid for passage of a flexible endoscope into the duodenum of dogs.

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