Pharmacokinetics and synovial fluid concentrations of cephapirin in calves with suppurative arthritis

Murray P. Brown From the Departments of Large Animal Clinical Sciences (Brown, Gronwall, Pattio, Houston) and Small Animal Clinical Sciences (Poulos), College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136.

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 DVM, MS
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Ronald R. Gronwall From the Departments of Large Animal Clinical Sciences (Brown, Gronwall, Pattio, Houston) and Small Animal Clinical Sciences (Poulos), College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136.

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Nolton Pattio From the Departments of Large Animal Clinical Sciences (Brown, Gronwall, Pattio, Houston) and Small Animal Clinical Sciences (Poulos), College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136.

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Paul W. Poulos From the Departments of Large Animal Clinical Sciences (Brown, Gronwall, Pattio, Houston) and Small Animal Clinical Sciences (Poulos), College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136.

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A. E. Houston From the Departments of Large Animal Clinical Sciences (Brown, Gronwall, Pattio, Houston) and Small Animal Clinical Sciences (Poulos), College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136.

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 BA

Summary

Six calves with suppurative arthritis were given a single im injection of sodium cephapirin at a dosage of 10 mg/kg of body weight. Cephapirin concentrations were serially measured in serum and in normal and suppurative synovial fluid over a 24-hour period. Mean peak serum concentration was 6.33 μl/ml at 20 minutes after injection. The highest cephapirin concentrations in normal and suppurative synovial fluid were 1.68 and 1.96 μg/ml, respectively, 30 minutes after injection. Overall mean cephapirin concentration in normal synovial fluid for the first 4 hours (1.04 ± 0.612 μg/ml) was not significantly different from that in suppurative synovial fluid (0.88 ± 0.495 μg/ml; P > 0.05). Elimination half-life was 0.60 hours and clearance was 1,593 ml/h/kg.

Summary

Six calves with suppurative arthritis were given a single im injection of sodium cephapirin at a dosage of 10 mg/kg of body weight. Cephapirin concentrations were serially measured in serum and in normal and suppurative synovial fluid over a 24-hour period. Mean peak serum concentration was 6.33 μl/ml at 20 minutes after injection. The highest cephapirin concentrations in normal and suppurative synovial fluid were 1.68 and 1.96 μg/ml, respectively, 30 minutes after injection. Overall mean cephapirin concentration in normal synovial fluid for the first 4 hours (1.04 ± 0.612 μg/ml) was not significantly different from that in suppurative synovial fluid (0.88 ± 0.495 μg/ml; P > 0.05). Elimination half-life was 0.60 hours and clearance was 1,593 ml/h/kg.

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