Effects of amnion and live yeast cell derivative on second-intention healing in horses

R. B. Bigbie From the Departments of Large Animal Surgery and Medicine (Bigbie, Schumacher, Purohit) Scott-Ritchey Research Laboratories, and Small Animal Surgery and Medicine (Swaim) and Pathobiology (Wright), College of Veterinary Medicine, Auburn University, AL 36849-5522.

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J. Schumacher From the Departments of Large Animal Surgery and Medicine (Bigbie, Schumacher, Purohit) Scott-Ritchey Research Laboratories, and Small Animal Surgery and Medicine (Swaim) and Pathobiology (Wright), College of Veterinary Medicine, Auburn University, AL 36849-5522.

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S. F. Swaim From the Departments of Large Animal Surgery and Medicine (Bigbie, Schumacher, Purohit) Scott-Ritchey Research Laboratories, and Small Animal Surgery and Medicine (Swaim) and Pathobiology (Wright), College of Veterinary Medicine, Auburn University, AL 36849-5522.

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R. C. Purohit From the Departments of Large Animal Surgery and Medicine (Bigbie, Schumacher, Purohit) Scott-Ritchey Research Laboratories, and Small Animal Surgery and Medicine (Swaim) and Pathobiology (Wright), College of Veterinary Medicine, Auburn University, AL 36849-5522.

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J. C. Wright From the Departments of Large Animal Surgery and Medicine (Bigbie, Schumacher, Purohit) Scott-Ritchey Research Laboratories, and Small Animal Surgery and Medicine (Swaim) and Pathobiology (Wright), College of Veterinary Medicine, Auburn University, AL 36849-5522.

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Summary

Equine amnion and live yeast cell derivative were evaluated as a biological dressing and as a topical wound medicament respectively, in the treatment of granulating wounds of the distal portion of the limbs of horses. Wounds measuring 2.5 × 2.5 cm were created on the dorsomedial aspect of the metacarpal and metatarsal region of all 4 limbs of 9 horses. Each wound was assigned randomly to 1 of 3 treatment groups: group C, treated with a nonadherent bandage as a control; group A, treated with amnion beneath a nonadherent bandage; and group L, treated with live yeast cell derivative beneath a nonadherent bandage. Rates of contraction and epithelialization were not significantly different among groups. Percentage of epithelialization for group A was significantly greater throughout the study than for the other groups. Number of days to complete healing was significantly less in group A and significantly greater in group L than in group C. Incidence and severity of exuberant granulation tissue were significantly less in group A than in the other 2 groups. Group L had more frequent and severe cases of exuberant granulation tissue than the other 2 groups.

Summary

Equine amnion and live yeast cell derivative were evaluated as a biological dressing and as a topical wound medicament respectively, in the treatment of granulating wounds of the distal portion of the limbs of horses. Wounds measuring 2.5 × 2.5 cm were created on the dorsomedial aspect of the metacarpal and metatarsal region of all 4 limbs of 9 horses. Each wound was assigned randomly to 1 of 3 treatment groups: group C, treated with a nonadherent bandage as a control; group A, treated with amnion beneath a nonadherent bandage; and group L, treated with live yeast cell derivative beneath a nonadherent bandage. Rates of contraction and epithelialization were not significantly different among groups. Percentage of epithelialization for group A was significantly greater throughout the study than for the other groups. Number of days to complete healing was significantly less in group A and significantly greater in group L than in group C. Incidence and severity of exuberant granulation tissue were significantly less in group A than in the other 2 groups. Group L had more frequent and severe cases of exuberant granulation tissue than the other 2 groups.

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