Acute effects of anti-inflammatory drugs on neodymium:yttrium aluminum garnet laser-induced uveitis in dogs

Nicholas J. Millichamp From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine (Millichamp, Dziezyc), the Institute of Ocular Pharmacology, College of Medicine (Rohde, Chiou), and the Department of Statistics (Smith), Texas A&M University, College Station, TX 77843.

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Joan Dziezyc From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine (Millichamp, Dziezyc), the Institute of Ocular Pharmacology, College of Medicine (Rohde, Chiou), and the Department of Statistics (Smith), Texas A&M University, College Station, TX 77843.

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Brooks H. Rohde From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine (Millichamp, Dziezyc), the Institute of Ocular Pharmacology, College of Medicine (Rohde, Chiou), and the Department of Statistics (Smith), Texas A&M University, College Station, TX 77843.

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George C. Y. Chiou From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine (Millichamp, Dziezyc), the Institute of Ocular Pharmacology, College of Medicine (Rohde, Chiou), and the Department of Statistics (Smith), Texas A&M University, College Station, TX 77843.

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William B. Smith From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine (Millichamp, Dziezyc), the Institute of Ocular Pharmacology, College of Medicine (Rohde, Chiou), and the Department of Statistics (Smith), Texas A&M University, College Station, TX 77843.

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Summary

Dogs were treated with flunixin meglumine, a cyclooxygenase inhibitor; L-651,896, a 5-lipoxygenase inhibitor; and matrine, a herbal anti-inflammatory drug. Acute inflammation was induced in the eyes by disruption of the anterior lens capsule, using a neodymium:yttrium aluminum garnet laser. Intraocular pressure, pupil diameter, and eicosanoid production in the aqueous humor were measured. Statistically significant effects were seen in the eyes of flunixin meglumine-treated dogs where mydriasis was maintained and aqueous prostaglandin E2 concentration was reduced.

Summary

Dogs were treated with flunixin meglumine, a cyclooxygenase inhibitor; L-651,896, a 5-lipoxygenase inhibitor; and matrine, a herbal anti-inflammatory drug. Acute inflammation was induced in the eyes by disruption of the anterior lens capsule, using a neodymium:yttrium aluminum garnet laser. Intraocular pressure, pupil diameter, and eicosanoid production in the aqueous humor were measured. Statistically significant effects were seen in the eyes of flunixin meglumine-treated dogs where mydriasis was maintained and aqueous prostaglandin E2 concentration was reduced.

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