Comparison of fractional excretion and 24-hour urinary excretion of sodium and potassium in clinically normal cats and cats with induced chronic renal failure

Larry G. Adams From the Departments of Small Animal Clinical Sciences (Adams, Polzin, Osborne) and Veterinary Pathobiology (O’Brien), College of Veterinary Medicine, 1352 Boyd Ave, University of Minnesota, St Paul, MN 55108.

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David J. Polzin From the Departments of Small Animal Clinical Sciences (Adams, Polzin, Osborne) and Veterinary Pathobiology (O’Brien), College of Veterinary Medicine, 1352 Boyd Ave, University of Minnesota, St Paul, MN 55108.

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Carl A. Osborne From the Departments of Small Animal Clinical Sciences (Adams, Polzin, Osborne) and Veterinary Pathobiology (O’Brien), College of Veterinary Medicine, 1352 Boyd Ave, University of Minnesota, St Paul, MN 55108.

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Timothy D. O’Brien From the Departments of Small Animal Clinical Sciences (Adams, Polzin, Osborne) and Veterinary Pathobiology (O’Brien), College of Veterinary Medicine, 1352 Boyd Ave, University of Minnesota, St Paul, MN 55108.

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SUMMARY

The influence of induced chronic renal failure on 24- hour urinary excretion and fractional excretion of sodium and potassium was studied in cats. Induction of chronic renal failure significantly increased fractional excretion of potassium (P < 0.0001) and sodium (P < 0.05); however, 24-hour urinary excretion of sodium and potassium decreased slightly following induction of chronic renal failure.

Fractional excretion and 24-hour urinary excretion of sodium and potassium were compared by linear regression in clinically normal cats, cats with chronic renal failure, and clinically normal and affected cats combined. In clinically normal cats, linear regression revealed only moderate correlation between fractional excretion and 24- hour urinary excretion for sodium and potassium. Linear regression of these same relationships in cats with chronic renal failure, and in clinically normal cats and cats with chronic renal failure combined, indicated low correlation.

Fractional excretions of sodium and potassium were not reliable indicators of 24-hour urinary excretion of these electrolytes in cats with chronic renal failure or unknown glomerular filtration rate. Fractional excretion of potassium and sodium correlated only moderately with 24-hour urinary excretion in clinically normal cats.

SUMMARY

The influence of induced chronic renal failure on 24- hour urinary excretion and fractional excretion of sodium and potassium was studied in cats. Induction of chronic renal failure significantly increased fractional excretion of potassium (P < 0.0001) and sodium (P < 0.05); however, 24-hour urinary excretion of sodium and potassium decreased slightly following induction of chronic renal failure.

Fractional excretion and 24-hour urinary excretion of sodium and potassium were compared by linear regression in clinically normal cats, cats with chronic renal failure, and clinically normal and affected cats combined. In clinically normal cats, linear regression revealed only moderate correlation between fractional excretion and 24- hour urinary excretion for sodium and potassium. Linear regression of these same relationships in cats with chronic renal failure, and in clinically normal cats and cats with chronic renal failure combined, indicated low correlation.

Fractional excretions of sodium and potassium were not reliable indicators of 24-hour urinary excretion of these electrolytes in cats with chronic renal failure or unknown glomerular filtration rate. Fractional excretion of potassium and sodium correlated only moderately with 24-hour urinary excretion in clinically normal cats.

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