Evaluation of intravenous administration of concentrated immunoglobulin G to colostrum-deprived foals

Irwin K. M. Liu From the Department of Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616-8743 (Liu), the Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824-1314 (Brown), the Michigan Department of Public Health, Lansing, MI 48909 (Myers), and Biotech Research Laboratories Inc, 1600 East Gude, Rockville, MD 20850 (Hao).

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Christopher Brown From the Department of Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616-8743 (Liu), the Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824-1314 (Brown), the Michigan Department of Public Health, Lansing, MI 48909 (Myers), and Biotech Research Laboratories Inc, 1600 East Gude, Rockville, MD 20850 (Hao).

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Robert C. Myers From the Department of Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616-8743 (Liu), the Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824-1314 (Brown), the Michigan Department of Public Health, Lansing, MI 48909 (Myers), and Biotech Research Laboratories Inc, 1600 East Gude, Rockville, MD 20850 (Hao).

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Yu Lee Hao From the Department of Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616-8743 (Liu), the Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824-1314 (Brown), the Michigan Department of Public Health, Lansing, MI 48909 (Myers), and Biotech Research Laboratories Inc, 1600 East Gude, Rockville, MD 20850 (Hao).

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SUMMARY

Ten foals of various breeds were deprived of colostrum from birth to 36 hours of age, then were allotted to 2 groups. Foals of group 1 (n = 6) were given 20 g (200 ml) of purified equine IgG iv in a 10% solution, and foals of group 2 (n = 4) were given 30 g (300 ml) of the same preparation. Total administration time for each 10 g of IgG in 100 ml was approximately 10 minutes. Serum IgG concentration in foals was assessed prior to, between 24 and 48 hours, and at 7 and 14 days after IgG administration.

Between 24 and 48 hours after IgG administration, mean serum IgG concentration in group-1 foals was 425 mg/dl (range, 350 to 480 mg/dl). Mean body weight for this group of foals was 50.3 kg (range, 43.3 to 54.7 kg).

For group-2 foals, mean serum IgG concentration was 768 mg/dl (range, 640 to 920 mg/dl) between 24 and 48 hours after administration of IgG. Foals of this group had mean body weight of 43.2 kg (range, 36.5 to 47.5 kg). Serum IgG concentration in group-2 foals at 24 to 48 hours was significantly (P = 0.005) greater than that in group- 1 foals.

Mean total IgG recovery at 24 to 48 hours, calculated on the basis of 94.5 ml of plasma volume/kg of body weight, was approximately 100%.

Values of IgG measured in all foals 1 and 2 weeks after administration of the IgG concentrate were equivalent to values expected after normal decay of passively acquired IgG. Mild, adverse reactions occurred in 3 of the 10 foals treated (1 group-1 foal and 2 group-2 foals).

SUMMARY

Ten foals of various breeds were deprived of colostrum from birth to 36 hours of age, then were allotted to 2 groups. Foals of group 1 (n = 6) were given 20 g (200 ml) of purified equine IgG iv in a 10% solution, and foals of group 2 (n = 4) were given 30 g (300 ml) of the same preparation. Total administration time for each 10 g of IgG in 100 ml was approximately 10 minutes. Serum IgG concentration in foals was assessed prior to, between 24 and 48 hours, and at 7 and 14 days after IgG administration.

Between 24 and 48 hours after IgG administration, mean serum IgG concentration in group-1 foals was 425 mg/dl (range, 350 to 480 mg/dl). Mean body weight for this group of foals was 50.3 kg (range, 43.3 to 54.7 kg).

For group-2 foals, mean serum IgG concentration was 768 mg/dl (range, 640 to 920 mg/dl) between 24 and 48 hours after administration of IgG. Foals of this group had mean body weight of 43.2 kg (range, 36.5 to 47.5 kg). Serum IgG concentration in group-2 foals at 24 to 48 hours was significantly (P = 0.005) greater than that in group- 1 foals.

Mean total IgG recovery at 24 to 48 hours, calculated on the basis of 94.5 ml of plasma volume/kg of body weight, was approximately 100%.

Values of IgG measured in all foals 1 and 2 weeks after administration of the IgG concentrate were equivalent to values expected after normal decay of passively acquired IgG. Mild, adverse reactions occurred in 3 of the 10 foals treated (1 group-1 foal and 2 group-2 foals).

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