Comparative studies on bioavailability and tissue uptake of two intraruminally or intraperitoneally administered esters of α-tocopherol in sheep

M. Hidiroglou From the Animal Research Centre, Ottawa, Ontario, Canada K1A 0C6.

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E. Charmley From the Animal Research Centre, Ottawa, Ontario, Canada K1A 0C6.

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SUMMARY

An experiment was conducted to compare the bioavailability of dl-α-tocopherol acetate (ta) with that of dl-α-tocopherol nicotinate (tn) when administered to sheep, as a single dose, either into the rumen or the peritoneal cavity. A total of 16 sheep were used in a factorial design, with 4 sheep/treatment at the interaction level. In addition, 5 sheep that received no supplemental α-tocopherol, were euthanatized at the end of the trial to provide baseline data for tissue α-tocopherol concentrations. Curves were fitted to the plasma α-tocopherol concentration values, taken over 180 hours after administration of the esters. Availability of ta was greater than tn, as evidenced by the significantly higher curve parameter values (P < 0.05) and tissue concentrations (P < 0.05). Route of administration had a marked effect on availability of ta (P < 0.001), but not of tn.

SUMMARY

An experiment was conducted to compare the bioavailability of dl-α-tocopherol acetate (ta) with that of dl-α-tocopherol nicotinate (tn) when administered to sheep, as a single dose, either into the rumen or the peritoneal cavity. A total of 16 sheep were used in a factorial design, with 4 sheep/treatment at the interaction level. In addition, 5 sheep that received no supplemental α-tocopherol, were euthanatized at the end of the trial to provide baseline data for tissue α-tocopherol concentrations. Curves were fitted to the plasma α-tocopherol concentration values, taken over 180 hours after administration of the esters. Availability of ta was greater than tn, as evidenced by the significantly higher curve parameter values (P < 0.05) and tissue concentrations (P < 0.05). Route of administration had a marked effect on availability of ta (P < 0.001), but not of tn.

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