Lesions and localization of viral antigen in tissues of cattle with experimentally induced or naturally acquired muscosal disease, or with naturally acquired chronic bovine viral diarrhea

Catherine L. Wilhelmsen From the Department of Veterinary Pathology, Iowa State University, Ames, IA 50011 (Wilhelmsen, Kluge), and the USDA, Agricultural Research Service, National Animal Disease Center, PO Box 70, Ames, IA 50010 (Bolin, Ridpath, Cheville).

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Steven R. Bolin From the Department of Veterinary Pathology, Iowa State University, Ames, IA 50011 (Wilhelmsen, Kluge), and the USDA, Agricultural Research Service, National Animal Disease Center, PO Box 70, Ames, IA 50010 (Bolin, Ridpath, Cheville).

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Julia F. Ridpath From the Department of Veterinary Pathology, Iowa State University, Ames, IA 50011 (Wilhelmsen, Kluge), and the USDA, Agricultural Research Service, National Animal Disease Center, PO Box 70, Ames, IA 50010 (Bolin, Ridpath, Cheville).

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Norman F. Cheville From the Department of Veterinary Pathology, Iowa State University, Ames, IA 50011 (Wilhelmsen, Kluge), and the USDA, Agricultural Research Service, National Animal Disease Center, PO Box 70, Ames, IA 50010 (Bolin, Ridpath, Cheville).

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John P. Kluge From the Department of Veterinary Pathology, Iowa State University, Ames, IA 50011 (Wilhelmsen, Kluge), and the USDA, Agricultural Research Service, National Animal Disease Center, PO Box 70, Ames, IA 50010 (Bolin, Ridpath, Cheville).

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DOI:
https://doi.org/10.2460/ajvr.1991.52.02.269
Volume/Issue:
Volume 52: Issue 2
Received:
10 Oct 1989
|
Online Publication Date:
01 Feb 1991
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SUMMARY

Tissues from cattle that died of experimentally induced mucosal disease (n = 3), naturally acquired mucosal disease (n = 6), or naturally acquired chronic bovine viral diarrhea (n = 4) were examined. Consistent findings were lymphocytic depletion of lymphoid tissues, degeneration of myenteric ganglion cells, and mild adrenalitis. Intracytoplasmic viral antigen was detected in myenteric ganglia and in endocrine glandular cells. Noncytopathic virus was isolated from all cattle, and cytopathic virus was isolated from 12 of 13 cattle.

SUMMARY

Tissues from cattle that died of experimentally induced mucosal disease (n = 3), naturally acquired mucosal disease (n = 6), or naturally acquired chronic bovine viral diarrhea (n = 4) were examined. Consistent findings were lymphocytic depletion of lymphoid tissues, degeneration of myenteric ganglion cells, and mild adrenalitis. Intracytoplasmic viral antigen was detected in myenteric ganglia and in endocrine glandular cells. Noncytopathic virus was isolated from all cattle, and cytopathic virus was isolated from 12 of 13 cattle.

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Cover American Journal of Veterinary Research
American Journal of Veterinary Research
Publication Date:
01 Feb 1991
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