SUMMARY
The urine-blood carbon dioxide tension (Pco2) gradient was measured in 10 healthy mature Beagles after alkalinization of the urine by administration of sodium bicarbonate. The mean (± sd) urine-blood Pco2 gradient was 65.92 ± 14.42 mm of Hg, with range of 38.2 to 82.2 mm of Hg. Mean urine Pco2 was 110.21 ± 14.19 mm of Hg, with range of 84.1 to 127.3 mm of Hg. Because urine-blood Pco2 gradient < 30.0 mm of Hg or urine Pco2 < 55 mm of Hg in people is diagnostic for a defect in distal nephron acidification, similar values might be applicable to diseases in dogs.