Urine-blood carbon dioxide tension gradient in healthy dogs

Darcy H. Shaw From the Department of Companion Animals, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island, Canada, CIA 4P3.

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 DVM, MVSc

SUMMARY

The urine-blood carbon dioxide tension (Pco2) gradient was measured in 10 healthy mature Beagles after alkalinization of the urine by administration of sodium bicarbonate. The mean (± sd) urine-blood Pco2 gradient was 65.92 ± 14.42 mm of Hg, with range of 38.2 to 82.2 mm of Hg. Mean urine Pco2 was 110.21 ± 14.19 mm of Hg, with range of 84.1 to 127.3 mm of Hg. Because urine-blood Pco2 gradient < 30.0 mm of Hg or urine Pco2 < 55 mm of Hg in people is diagnostic for a defect in distal nephron acidification, similar values might be applicable to diseases in dogs.

SUMMARY

The urine-blood carbon dioxide tension (Pco2) gradient was measured in 10 healthy mature Beagles after alkalinization of the urine by administration of sodium bicarbonate. The mean (± sd) urine-blood Pco2 gradient was 65.92 ± 14.42 mm of Hg, with range of 38.2 to 82.2 mm of Hg. Mean urine Pco2 was 110.21 ± 14.19 mm of Hg, with range of 84.1 to 127.3 mm of Hg. Because urine-blood Pco2 gradient < 30.0 mm of Hg or urine Pco2 < 55 mm of Hg in people is diagnostic for a defect in distal nephron acidification, similar values might be applicable to diseases in dogs.

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