Chemoprophylactic effects of milbemycin oxime against larvae of Dirofilaria immitis during prepatent development

Robert B. Grieve From the Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 (Grieve, Frank, Stewart, Parsons, Belasco) and Ciba-Geigy Corp, Agricultural Division, Greensboro, NC 27149 (Hepler).

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 PhD
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Glenn R. Frank From the Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 (Grieve, Frank, Stewart, Parsons, Belasco) and Ciba-Geigy Corp, Agricultural Division, Greensboro, NC 27149 (Hepler).

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 DVM, MS
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V. Ann Stewart From the Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 (Grieve, Frank, Stewart, Parsons, Belasco) and Ciba-Geigy Corp, Agricultural Division, Greensboro, NC 27149 (Hepler).

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Jim C. Parsons From the Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 (Grieve, Frank, Stewart, Parsons, Belasco) and Ciba-Geigy Corp, Agricultural Division, Greensboro, NC 27149 (Hepler).

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Debra L. Belasco From the Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 (Grieve, Frank, Stewart, Parsons, Belasco) and Ciba-Geigy Corp, Agricultural Division, Greensboro, NC 27149 (Hepler).

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Douglas I. Hepler From the Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 (Grieve, Frank, Stewart, Parsons, Belasco) and Ciba-Geigy Corp, Agricultural Division, Greensboro, NC 27149 (Hepler).

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SUMMARY

Three studies were conducted to determine the efficacy of milbemycin oxime in the prevention of Dirofilaria immitis infection in dogs. Dogs were given single or multiple experimental inoculations with infective third-stage D immitis larvae and were treated with milbemycin oxime at a target dosage of 0.5 mg/kg of body weight either once or at monthly intervals at various times after inoculation. The compound was effective in preventing infection when 1 dose was administered 30 or 45 days after inoculation. Significant, but incomplete, protection was achieved when single treatments were administered 60 or 90 days after inoculation. Multiple monthly treatments beginning 60 days after inoculation appeared to provide additive effects that resulted in restoration of complete efficacy.

SUMMARY

Three studies were conducted to determine the efficacy of milbemycin oxime in the prevention of Dirofilaria immitis infection in dogs. Dogs were given single or multiple experimental inoculations with infective third-stage D immitis larvae and were treated with milbemycin oxime at a target dosage of 0.5 mg/kg of body weight either once or at monthly intervals at various times after inoculation. The compound was effective in preventing infection when 1 dose was administered 30 or 45 days after inoculation. Significant, but incomplete, protection was achieved when single treatments were administered 60 or 90 days after inoculation. Multiple monthly treatments beginning 60 days after inoculation appeared to provide additive effects that resulted in restoration of complete efficacy.

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