Dose response to butorphanol administered subcutaneously to increase visceral nociceptive threshold in dogs

Donald C. Sawyer From the Departments of Small Animal Clinical Sciences (Sawyer, Durham, Langham, Striler), Pharmacology and Toxicology (Sawyer, Rech) and Physiology (Adams), College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824-1314.

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Richard H. Rech From the Departments of Small Animal Clinical Sciences (Sawyer, Durham, Langham, Striler), Pharmacology and Toxicology (Sawyer, Rech) and Physiology (Adams), College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824-1314.

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Robert A. Durham From the Departments of Small Animal Clinical Sciences (Sawyer, Durham, Langham, Striler), Pharmacology and Toxicology (Sawyer, Rech) and Physiology (Adams), College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824-1314.

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Thomas Adams From the Departments of Small Animal Clinical Sciences (Sawyer, Durham, Langham, Striler), Pharmacology and Toxicology (Sawyer, Rech) and Physiology (Adams), College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824-1314.

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Marlee A. Richter From the Departments of Small Animal Clinical Sciences (Sawyer, Durham, Langham, Striler), Pharmacology and Toxicology (Sawyer, Rech) and Physiology (Adams), College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824-1314.

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Elaine L. Striler From the Departments of Small Animal Clinical Sciences (Sawyer, Durham, Langham, Striler), Pharmacology and Toxicology (Sawyer, Rech) and Physiology (Adams), College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824-1314.

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SUMMARY

Butorphanol (0.025, 0.05, 0.1, 0.2, 0.4, and 0.8 mg/kg of body weight, and placebo) was given sc to 8 healthy unmedicated dogs to determine its efficacy for visceral analgesia, using a colonic balloon for minimal threshold nociceptor stimulation. Degree of sedation; systolic, diastolic, and mean arterial pressure; and pulse rate were recorded. The highest 3 dosages, 0.2, 0.4, and 0.8 mg/kg, were found to be most effective, with 0.8 mg/kg the only dosage that was significantly different from control responses at the 45-minute interval. Duration of analgesia ranged from 23 to 53 minutes for all 6 dosages and dosing durations were not significantly different from one another. Blood pressures did not change, but pulse rate was significantly decreased by 0.8 mg of butorphanol/kg. We concluded that butorphanol is an effective visceral analgesic of relatively short duration in the dog.

SUMMARY

Butorphanol (0.025, 0.05, 0.1, 0.2, 0.4, and 0.8 mg/kg of body weight, and placebo) was given sc to 8 healthy unmedicated dogs to determine its efficacy for visceral analgesia, using a colonic balloon for minimal threshold nociceptor stimulation. Degree of sedation; systolic, diastolic, and mean arterial pressure; and pulse rate were recorded. The highest 3 dosages, 0.2, 0.4, and 0.8 mg/kg, were found to be most effective, with 0.8 mg/kg the only dosage that was significantly different from control responses at the 45-minute interval. Duration of analgesia ranged from 23 to 53 minutes for all 6 dosages and dosing durations were not significantly different from one another. Blood pressures did not change, but pulse rate was significantly decreased by 0.8 mg of butorphanol/kg. We concluded that butorphanol is an effective visceral analgesic of relatively short duration in the dog.

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