Use of nonimaging nuclear medicine techniques to assess the effect of flunixin meglumine on effective renal plasma flow and effective renal blood flow in healthy horses

J. P. Held From the Departments of Rural Practice (Held) and Urban Practice (Daniel), College of Veterinary Medicine, University of Tennessee, PO Box 1071, Knoxville, TN 37901-1071.

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Gregory B. Daniel From the Departments of Rural Practice (Held) and Urban Practice (Daniel), College of Veterinary Medicine, University of Tennessee, PO Box 1071, Knoxville, TN 37901-1071.

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SUMMARY

The effect of flunixin meglumine on renal function was studied in 6 healthy horses by use of nonimaging nuclear medicine techniques. Effective renal plasma flow (erpf) and effective renal blood flow (erbf) were determined by plasma clearance of 131I-orthoiodohippuric acid before and after administration of flunixin meglumine. Mean erpf and erbf was 6.03 ml/min/kg and 10.7 ml/min/kg, respectively, before treatment and was 5.7 ml/min/kg and 9.7 ml/min/kg, respectively, after treatment. Although erpf and erbf decreased after flunixin meglumine administration, the difference was not statistically significant.

SUMMARY

The effect of flunixin meglumine on renal function was studied in 6 healthy horses by use of nonimaging nuclear medicine techniques. Effective renal plasma flow (erpf) and effective renal blood flow (erbf) were determined by plasma clearance of 131I-orthoiodohippuric acid before and after administration of flunixin meglumine. Mean erpf and erbf was 6.03 ml/min/kg and 10.7 ml/min/kg, respectively, before treatment and was 5.7 ml/min/kg and 9.7 ml/min/kg, respectively, after treatment. Although erpf and erbf decreased after flunixin meglumine administration, the difference was not statistically significant.

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