Effects of intra-articular administration of methylprednisolone acetate on normal equine articular cartilage

Gayle W. Trotter From the Departments of Clinical Sciences (Trotter, McIlwraith, Yovich), Pathology (Norrdin), and Radiology and Radiation Biology (Wrigley), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Co 80523, and the Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907 (Lamar).

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C. Wayne McIlwraith From the Departments of Clinical Sciences (Trotter, McIlwraith, Yovich), Pathology (Norrdin), and Radiology and Radiation Biology (Wrigley), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Co 80523, and the Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907 (Lamar).

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John V. Yovich From the Departments of Clinical Sciences (Trotter, McIlwraith, Yovich), Pathology (Norrdin), and Radiology and Radiation Biology (Wrigley), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Co 80523, and the Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907 (Lamar).

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Robert W. Norrdin From the Departments of Clinical Sciences (Trotter, McIlwraith, Yovich), Pathology (Norrdin), and Radiology and Radiation Biology (Wrigley), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Co 80523, and the Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907 (Lamar).

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Robert H. Wrigley From the Departments of Clinical Sciences (Trotter, McIlwraith, Yovich), Pathology (Norrdin), and Radiology and Radiation Biology (Wrigley), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Co 80523, and the Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907 (Lamar).

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C. H. Lamar From the Departments of Clinical Sciences (Trotter, McIlwraith, Yovich), Pathology (Norrdin), and Radiology and Radiation Biology (Wrigley), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Co 80523, and the Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907 (Lamar).

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SUMMARY

The effects of the corticosteroid 6-α-methylprednisolone acetate on normal equine articular cartilage were evaluated, using the middle carpal joint in 4 clinically normal young horses. One middle carpal joint of each horse was injected 3 times with 100 mg of 6-α-methylprednisolone acetate, at 14-day intervals. The opposite middle carpal joint (control) was injected with 2.5 ml of lactated Ringer solution at the same intervals. Effects were studied until 8 weeks after the first injection. Evaluation included clinical and radiographic examination, and gross, microscopic, and biochemical evaluation of joint tissues.

Horses remained clinically normal during the study, and significant radiographic changes were not observed. Safranin-0 matrix staining intensity and uronic acid content were significantly (P < 0.05) lower and hydroxyproline content was significantly (P < 0.05) higher in articular cartilage of corticosteroid-injected joints vs control joints.

SUMMARY

The effects of the corticosteroid 6-α-methylprednisolone acetate on normal equine articular cartilage were evaluated, using the middle carpal joint in 4 clinically normal young horses. One middle carpal joint of each horse was injected 3 times with 100 mg of 6-α-methylprednisolone acetate, at 14-day intervals. The opposite middle carpal joint (control) was injected with 2.5 ml of lactated Ringer solution at the same intervals. Effects were studied until 8 weeks after the first injection. Evaluation included clinical and radiographic examination, and gross, microscopic, and biochemical evaluation of joint tissues.

Horses remained clinically normal during the study, and significant radiographic changes were not observed. Safranin-0 matrix staining intensity and uronic acid content were significantly (P < 0.05) lower and hydroxyproline content was significantly (P < 0.05) higher in articular cartilage of corticosteroid-injected joints vs control joints.

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