Alteration in intestinal morphologic features associated with extensive large-colon resection in horses

Alicia L. Bertone From the Departments of Clinical Sciences (Bertone, Stashak), Pathology Cockerell) and Anatomy (Lee), College of Veterinary Medicine and Biological sciences, Colorado State University, Fort Collins, CO 80523.

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Gary L. Cockerell From the Departments of Clinical Sciences (Bertone, Stashak), Pathology Cockerell) and Anatomy (Lee), College of Veterinary Medicine and Biological sciences, Colorado State University, Fort Collins, CO 80523.

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Robert E. Lee From the Departments of Clinical Sciences (Bertone, Stashak), Pathology Cockerell) and Anatomy (Lee), College of Veterinary Medicine and Biological sciences, Colorado State University, Fort Collins, CO 80523.

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Ted S. Stashak From the Departments of Clinical Sciences (Bertone, Stashak), Pathology Cockerell) and Anatomy (Lee), College of Veterinary Medicine and Biological sciences, Colorado State University, Fort Collins, CO 80523.

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SUMMARY

Light microscopy, morphometry, and scanning electron microscopy were used to examine the mucosal morphologic features of 7 intestinal specimens (3 from the small intestine; 4 from the large intestine) from each of 8 horses 1 year after sham operation (group 1; n = 3) or extensive large-colon resection (group 2; n = 5). Qualitative light microscopic examination did not reveal differences between groups, but morphometry revealed significantly (P < 0.05) greater intercrypt area and distance in horses with colon resection and this was most pronounced in the cecum and remaining right ventral and dorsal colon. Crypt area and depth were similar for horses with colon resection and sham operation (P > 0.05). Qualitative evaluation of the scanning electron micrographs revealed more prominent crypt orifices in the large intestine of horses with colon resection. The larger intercrypt distance in the colon of horses with resection was not an obvious feature of the qualitative evaluation of the surface with scanning electron microscopy. Small intestinal morphologic features were variable and significant differences were not detected between horses with sham operation and colon resection. Horses adapted to extensive large-colon resection within 1 year by increasing the absorptive (intercrypt) surface area of the remaining large intestine.

SUMMARY

Light microscopy, morphometry, and scanning electron microscopy were used to examine the mucosal morphologic features of 7 intestinal specimens (3 from the small intestine; 4 from the large intestine) from each of 8 horses 1 year after sham operation (group 1; n = 3) or extensive large-colon resection (group 2; n = 5). Qualitative light microscopic examination did not reveal differences between groups, but morphometry revealed significantly (P < 0.05) greater intercrypt area and distance in horses with colon resection and this was most pronounced in the cecum and remaining right ventral and dorsal colon. Crypt area and depth were similar for horses with colon resection and sham operation (P > 0.05). Qualitative evaluation of the scanning electron micrographs revealed more prominent crypt orifices in the large intestine of horses with colon resection. The larger intercrypt distance in the colon of horses with resection was not an obvious feature of the qualitative evaluation of the surface with scanning electron microscopy. Small intestinal morphologic features were variable and significant differences were not detected between horses with sham operation and colon resection. Horses adapted to extensive large-colon resection within 1 year by increasing the absorptive (intercrypt) surface area of the remaining large intestine.

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