Comparison of plasma, liver, and skeletal muscle carnitine concentrations in cats with idiopathic hepatic lipidosis and in healthy cats

Gilbert Jacobs From the Department of Small Animal Medicine (Jacobs, Cornelius) and Diagnostic Laboratory (Rakich), College of Veterinary Medicine, University of Georgia, Athens, GA 30602; the Department of Medical Sciences (Keene), School of Veterinary Medicine, University of Wisconsin, and the Wm S. Middleton Memorial Veterans Administration Medical Center (Shug), Madison, WI 53705.

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Larry Cornelius From the Department of Small Animal Medicine (Jacobs, Cornelius) and Diagnostic Laboratory (Rakich), College of Veterinary Medicine, University of Georgia, Athens, GA 30602; the Department of Medical Sciences (Keene), School of Veterinary Medicine, University of Wisconsin, and the Wm S. Middleton Memorial Veterans Administration Medical Center (Shug), Madison, WI 53705.

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Bruce Keene From the Department of Small Animal Medicine (Jacobs, Cornelius) and Diagnostic Laboratory (Rakich), College of Veterinary Medicine, University of Georgia, Athens, GA 30602; the Department of Medical Sciences (Keene), School of Veterinary Medicine, University of Wisconsin, and the Wm S. Middleton Memorial Veterans Administration Medical Center (Shug), Madison, WI 53705.

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Pauline Rakich From the Department of Small Animal Medicine (Jacobs, Cornelius) and Diagnostic Laboratory (Rakich), College of Veterinary Medicine, University of Georgia, Athens, GA 30602; the Department of Medical Sciences (Keene), School of Veterinary Medicine, University of Wisconsin, and the Wm S. Middleton Memorial Veterans Administration Medical Center (Shug), Madison, WI 53705.

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Austin Shug From the Department of Small Animal Medicine (Jacobs, Cornelius) and Diagnostic Laboratory (Rakich), College of Veterinary Medicine, University of Georgia, Athens, GA 30602; the Department of Medical Sciences (Keene), School of Veterinary Medicine, University of Wisconsin, and the Wm S. Middleton Memorial Veterans Administration Medical Center (Shug), Madison, WI 53705.

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SUMMARY

Concentrations of total, free, and esterified carnitine were determined in plasma, liver, and skeletal muscle from cats with idiopathic hepatic lipidosis and compared with values from healthy cats. The mean concentrations of plasma, liver, and skeletal muscle total carnitine; plasma and skeletal muscle free carnitine; and plasma and liver esterified carnitine were greater (P < 0.05) in cats with idiopathic hepatic lipidosis than in control cats. The mean for the ratio of free/total carnitine in plasma and liver was lower (P < 0.05) in cats with idiopathic hepatic lipidosis than in control cats. These data suggest that carnitine deficiency does not contribute to the pathogenesis of feline idiopathic hepatic lipidosis.

SUMMARY

Concentrations of total, free, and esterified carnitine were determined in plasma, liver, and skeletal muscle from cats with idiopathic hepatic lipidosis and compared with values from healthy cats. The mean concentrations of plasma, liver, and skeletal muscle total carnitine; plasma and skeletal muscle free carnitine; and plasma and liver esterified carnitine were greater (P < 0.05) in cats with idiopathic hepatic lipidosis than in control cats. The mean for the ratio of free/total carnitine in plasma and liver was lower (P < 0.05) in cats with idiopathic hepatic lipidosis than in control cats. These data suggest that carnitine deficiency does not contribute to the pathogenesis of feline idiopathic hepatic lipidosis.

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