Plasma, tissue, and urine carnitine concentrations in healthy adult cats and kittens

Gilbert Jacobs From the Department of Small Animal Medicine (Jacobs, Cornelius) and the Diagnostic Laboratory (Rakich), College of Veterinary Medicine, University of Georgia, Athens, GA 30602; Department of Medical Sciences (Keene), School of Veterinary Medicine, University of Wisconsin, and the Wm S. Middleton Memorial Veterans Administration Medical Center (Shug), Madison, WI 53705.

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Bruce Keene From the Department of Small Animal Medicine (Jacobs, Cornelius) and the Diagnostic Laboratory (Rakich), College of Veterinary Medicine, University of Georgia, Athens, GA 30602; Department of Medical Sciences (Keene), School of Veterinary Medicine, University of Wisconsin, and the Wm S. Middleton Memorial Veterans Administration Medical Center (Shug), Madison, WI 53705.

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Larry M. Cornelius From the Department of Small Animal Medicine (Jacobs, Cornelius) and the Diagnostic Laboratory (Rakich), College of Veterinary Medicine, University of Georgia, Athens, GA 30602; Department of Medical Sciences (Keene), School of Veterinary Medicine, University of Wisconsin, and the Wm S. Middleton Memorial Veterans Administration Medical Center (Shug), Madison, WI 53705.

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Pauline Rakich From the Department of Small Animal Medicine (Jacobs, Cornelius) and the Diagnostic Laboratory (Rakich), College of Veterinary Medicine, University of Georgia, Athens, GA 30602; Department of Medical Sciences (Keene), School of Veterinary Medicine, University of Wisconsin, and the Wm S. Middleton Memorial Veterans Administration Medical Center (Shug), Madison, WI 53705.

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Austin Shug From the Department of Small Animal Medicine (Jacobs, Cornelius) and the Diagnostic Laboratory (Rakich), College of Veterinary Medicine, University of Georgia, Athens, GA 30602; Department of Medical Sciences (Keene), School of Veterinary Medicine, University of Wisconsin, and the Wm S. Middleton Memorial Veterans Administration Medical Center (Shug), Madison, WI 53705.

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SUMMARY

Mean carnitine concentrations ([carnitine]) were higher (P < 0.05) in adult cats than in kittens for skeletal muscle (total and free carnitine), myocardium (free carnitine), and urine (total and free carnitine). The free/total carnitine ratio was lower (P < 0.05) in kittens than in adults for liver, myocardium, and urine. Carnitine concentrations were similar between genders in kittens, but in adult cats, [carnitine] in plasma (total, free, and esterified carnitine) and liver (total and free carnitine) were higher (P < 0.05) in female than in male cats. Total and free plasma [carnitine] were correlated to total and free liver [carnitine], respectively. Skeletal muscle [carnitine] was not correlated to plasma [carnitine]. Correlations in [carnitine] between plasma and myocardium, kidney, or urine were inconsistent.

SUMMARY

Mean carnitine concentrations ([carnitine]) were higher (P < 0.05) in adult cats than in kittens for skeletal muscle (total and free carnitine), myocardium (free carnitine), and urine (total and free carnitine). The free/total carnitine ratio was lower (P < 0.05) in kittens than in adults for liver, myocardium, and urine. Carnitine concentrations were similar between genders in kittens, but in adult cats, [carnitine] in plasma (total, free, and esterified carnitine) and liver (total and free carnitine) were higher (P < 0.05) in female than in male cats. Total and free plasma [carnitine] were correlated to total and free liver [carnitine], respectively. Skeletal muscle [carnitine] was not correlated to plasma [carnitine]. Correlations in [carnitine] between plasma and myocardium, kidney, or urine were inconsistent.

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